Osteophytes, juxta-articular radiolucencies and cancellous bone changes in the proximal tibia of patients with knee osteoarthritis E.A. Messent, Ph.D.,

Slides:

Advertisements

Similar presentations

Validity and responsiveness of a new measure of knee osteophytes for osteoarthritis studies: data from the osteoarthritis initiative M. Hakky, M. Jarraya,

Advertisements

Effect of interval-training exercise on subchondral bone in a chemically-induced osteoarthritis model A. Boudenot, N. Presle, R. Uzbekov, H. Toumi, S.

Atlas of individual radiographic features in osteoarthritis, revised

Association between radiography-based subchondral bone structure and MRI-based cartilage composition in postmenopausal women with mild osteoarthritis

Osteoporosis increases the severity of cartilage damage in an experimental model of osteoarthritis in rabbits E. Calvo, M.D., S. Castañeda, M.D., R.

Increased risk for radiographic osteoarthritis features in young active athletes: a cross- sectional matched case–control study F.W. Roemer, M. Jarraya,

Subchondral bone remodeling is related to clinical improvement after joint distraction in the treatment of ankle osteoarthritis F. Intema, T.P. Thomas,

Long-term periarticular bone adaptation in a feline knee injury model for post-traumatic experimental osteoarthritis S.K. Boyd, Ph.D., R. Müller, Ph.D.,

Trabecular bone structure and spatial differences in articular cartilage MR relaxation times in individuals with posterior horn medial meniscal tears

Regional analysis of femorotibial cartilage loss in a subsample from the Osteoarthritis Initiative progression subcohort W. Wirth, M.S., M.-P. Hellio.

Critical molecular regulators, histomorphometric indices and their correlations in the trabecular bone in primary hip osteoarthritis D.D. Kumarasinghe,

ADAMTS5−/− mice have less subchondral bone changes after induction of osteoarthritis through surgical instability: implications for a link between cartilage.

Whole-body vibration of mice induces articular cartilage degeneration with minimal changes in subchondral bone M.R. McCann, C. Yeung, M.A. Pest, A. Ratneswaran,

Cartilage and bone changes during development of post-traumatic osteoarthritis in selected LGXSM recombinant inbred mice S. Hashimoto, M.F. Rai, K.L.

Associations between pre-operative radiographic changes and outcomes after total knee joint replacement for osteoarthritis M.M. Dowsey, M. Nikpour, P.

Relationships between tibial rim alignment and joint space width measurement reproducibility in non-fluoroscopic radiographs of osteoarthritic knees

Reference values and Z-scores for subregional femorotibial cartilage thickness – results from a large population-based sample (Framingham) and comparison.

Cartilage damage pattern in relation to subchondral plate thickness in a collagenase- induced model of osteoarthritis S.M. Botter, M.Sc., G.J.V.M. van.

Spatial and temporal changes of subchondral bone proceed to microscopic articular cartilage degeneration in guinea pigs with spontaneous osteoarthritis

Positron emission tomography with 18F-FDG in osteoarthritic knee

Cancellous bone changes in hip osteoarthritis: a short-term longitudinal study using fractal signature analysis C.D. Papaloucas, M.D., Ph.D., R.J. Ward,

Knee joint subchondral bone structure alterations in active athletes: a cross-sectional case–control study F.W. Roemer, M. Jarraya, J. Niu, J. Duryea,

Relationship between trabecular bone structure and articular cartilage morphology and relaxation times in early OA of the knee joint using parallel MRI.

Bone marrow lesions, subchondral bone cysts and subchondral bone attrition are associated with histological synovitis in patients with end-stage knee.

Cancellous bone differences between knees with early, definite and advanced joint space loss; a comparative quantitative macroradiographic study Elizabeth.

S. Reichenbach, M. D. , A. Guermazi, M. D. , J. Niu, M. B. B. S. , D

The chemokine receptor CCR5 plays a role in post-traumatic cartilage loss in mice, but does not affect synovium and bone K. Takebe, M.F. Rai, E.J. Schmidt,

The OARSI histopathology initiative – recommendations for histological assessments of osteoarthritis in the rat N. Gerwin, A.M. Bendele, S. Glasson,

Metabolic enrichment of omega-3 polyunsaturated fatty acids does not reduce the onset of idiopathic knee osteoarthritis in mice A. Cai, E. Hutchison,

Quantification of differences in bone texture from plain radiographs in knees with and without osteoarthritis J. Hirvasniemi, J. Thevenot, V. Immonen,

Differences in trabecular bone texture between knees with and without radiographic osteoarthritis detected by fractal methods P. Podsiadlo, Ph.D., L.

Histopathology grading systems for characterisation of human knee osteoarthritis – reproducibility, variability, reliability, correlation, and validity

Characterization of pro-apoptotic and matrix-degradative gene expression following induction of osteoarthritis in mature and aged rabbits Dr. C.M. Robertson,

Radiofrequency (RF) coil impacts the value and reproducibility of cartilage spin–spin (T2) relaxation time measurements B.J. Dardzinski, E. Schneider

Subchondral and epiphyseal bone remodeling following surgical transection and noninvasive rupture of the anterior cruciate ligament as models of post-traumatic.

Effects of a metalloproteinase inhibitor on osteochondral angiogenesis, chondropathy and pain behavior in a rat model of osteoarthritis P.I. Mapp, D.A.

J. Ranstam Osteoarthritis and Cartilage

Knee Images Digital Analysis (KIDA): a novel method to quantify individual radiographic features of knee osteoarthritis in detail A.C.A. Marijnissen,

Is increased joint loading detrimental to obese patients with knee osteoarthritis? A secondary data analysis from a randomized trial M. Henriksen, D.J.

Quantification of differences in bone texture from plain radiographs in knees with and without osteoarthritis J. Hirvasniemi, J. Thevenot, V. Immonen,

Quantitative regional and sub-regional analysis of femoral and tibial subchondral bone mineral density (sBMD) using computed tomography (CT): comparison.

In early OA, thinning of the subchondral plate is directly related to cartilage damage: results from a canine ACLT-meniscectomy model F. Intema, H.A.W.

Christopher Buckland-Wright, D.Sc Osteoarthritis and Cartilage

Loss of Frzb and Sfrp1 differentially affects joint homeostasis in instability-induced osteoarthritis S. Thysen, F.P. Luyten, R.J. Lories Osteoarthritis.

Pre-radiographic osteoarthritic changes are highly prevalent in the medial patella and medial posterior femur in older persons: Framingham OA study D.

M. A. Karsdal, M. Sc. , Ph. D. , D. J. Leeming, M. Sc. , E. B. Dam, M

Joint loading and proximal tibia subchondral trabecular bone microarchitecture differ with walking gait patterns in end-stage knee osteoarthritis B.C.

Subchondral tibial bone texture analysis predicts knee osteoarthritis progression: data from the Osteoarthritis Initiative T. Janvier, R. Jennane, A.

Volumetric bone mineral density of the tibia is not increased in subjects with radiographic knee osteoarthritis M. Abdin-Mohamed, M.B.B.S., M.R.C.P.,

C. E. Berger, M. D. , A. Kröner, M. D. , K. H. Kristen, M. D. , M

Tibial cancellous bone changes in patients with knee osteoarthritis

MRI-derived T2 relaxation times and cartilage morphometry of the tibio-femoral joint in subjects with and without osteoarthritis during a 1-year follow-up

X. Li, Ph. D. , C. Benjamin Ma, M. D. , T. M. Link, M. D. , D. -D

G. H. Lo, M. D. , M. Sc. , J. Niu, M. D. , D. Sc. , C. E. McLennan, M

A pilot study of the reproducibility and validity of measuring knee subchondral bone density in the tibia D. Dore, BBiotech.(Hons.), C. Ding, M.D., G.

Pre-emptive, early, and delayed alendronate treatment in a rat model of knee osteoarthritis: effect on subchondral trabecular bone microarchitecture and.

Changes to the articular cartilage thickness profile of the tibia following anterior cruciate ligament injury E.C. Argentieri, D.R. Sturnick, M.J. DeSarno,

Bone loss at subchondral plate in knee osteoarthritis patients with hypertension and type 2 diabetes mellitus C.Y. Wen, Y. Chen, H.L. Tang, C.H. Yan,

Alterations in subchondral bone plate, trabecular bone and articular cartilage properties of rabbit femoral condyles at 4 weeks after anterior cruciate.

Computed tomography topographic mapping of subchondral density (CT-TOMASD) in osteoarthritic and normal knees: methodological development and preliminary.

Most patients gain weight in the 2 years after total knee arthroplasty: comparison to a healthy control group J.A. Zeni, L. Snyder-Mackler Osteoarthritis.

In vivo structural analysis of subchondral trabecular bone in osteoarthritis of the hip using multi-detector row CT K. Chiba, M. Ito, M. Osaki, M. Uetani,

Longitudinal evaluation of T1ρ and T2 spatial distribution in osteoarthritic and healthy medial knee cartilage J. Schooler, D. Kumar, L. Nardo, C. McCulloch,

Osteoarthritis year 2012 in review: biology

Knee cartilage defects: association with early radiographic osteoarthritis, decreased cartilage volume, increased joint surface area and type II collagen.

G. Blumenkrantz, B. S. , R. Stahl, M. D. , J. Carballido-Gamio, Ph. D

M. Hudelmaier, W. Wirth Osteoarthritis and Cartilage

Preliminary study on diffraction enhanced radiographic imaging for a canine model of cartilage damage C. Muehleman, Ph.D., J. Li, M.D., Z. Zhong, Ph.D.

Osteoarthritis year in review 2016: mechanics

Osteoarthritis year 2012 in review: imaging

Presentation transcript:

Osteophytes, juxta-articular radiolucencies and cancellous bone changes in the proximal tibia of patients with knee osteoarthritis E.A. Messent, Ph.D., R.J. Ward, Ph.D., C.J. Tonkin, D.C.R.(R.), C. Buckland-Wright, D.Sc. Osteoarthritis and Cartilage Volume 15, Issue 2, Pages 179-186 (February 2007) DOI: 10.1016/j.joca.2006.06.020 Copyright © 2006 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 Macroradiograph (×4 magnification) of a right knee with medial compartment OA. Periarticular osteopenia is present within subchondral bone adjacent to the osteophyte growing at the margin of the medial compartment. Reproduced at ×3.9 magnification. Osteoarthritis and Cartilage 2007 15, 179-186DOI: (10.1016/j.joca.2006.06.020) Copyright © 2006 Osteoarthritis Research Society International Terms and Conditions

Fig. 2 Teaching macroradiographs (×4 magnification) for groups (a) OPH1 (marginal osteophyte equivalent to OARS grade >0, <1); (b) OPH2 (marginal osteophyte equivalent to OARS grade >1, <2); and (c) OPH3 (marginal osteophyte equivalent to OARS grade ≥2, 3). Arrow indicates osteophyte. Diameter of ball bearing=5mm. Osteoarthritis and Cartilage 2007 15, 179-186DOI: (10.1016/j.joca.2006.06.020) Copyright © 2006 Osteoarthritis Research Society International Terms and Conditions

Fig. 3 Macroradiograph (×4 magnification) of a proximal right tibia showing placement of the central weight-bearing (C) and marginal (M) ROIs. Broken line indicates the inferior margin of the cortical plate. Reproduced at ×3.9 magnification. Osteoarthritis and Cartilage 2007 15, 179-186DOI: (10.1016/j.joca.2006.06.020) Copyright © 2006 Osteoarthritis Research Society International Terms and Conditions

Fig. 4 The mean difference in FD for vertical (i) and horizontal (ii) trabecular structures between OA groups (OA1, OA2, and OA3) and the non-OA group (NOA) in the central weight-bearing (a) and marginal (b) regions of interest. Significant differences indicated at P<0.05 ■, P<0.01 ■, and P<0.001 □. Osteoarthritis and Cartilage 2007 15, 179-186DOI: (10.1016/j.joca.2006.06.020) Copyright © 2006 Osteoarthritis Research Society International Terms and Conditions

Fig. 5 Macerated preparations of lumbar vertebrae from subjects with ‘normal’ structure (a) and mild osteoporosis (b)38. The higher FSA values for vertical trabeculae (b) are due to the increase in number of cross-connectivity of fine trabecular structures. Osteoarthritis and Cartilage 2007 15, 179-186DOI: (10.1016/j.joca.2006.06.020) Copyright © 2006 Osteoarthritis Research Society International Terms and Conditions

Fig. 6 Schematic diagram showing the development of a tibial marginal osteophyte, with blood vessels from the periosteum invading the cartilage bud. Modified after Alonge et al.54. Osteoarthritis and Cartilage 2007 15, 179-186DOI: (10.1016/j.joca.2006.06.020) Copyright © 2006 Osteoarthritis Research Society International Terms and Conditions