Kinga K. Smolen, MSc, Candice E. Ruck, BSc, Edgardo S

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Presentation transcript:

Pattern recognition receptor-mediated cytokine response in infants across 4 continents⋆ Kinga K. Smolen, MSc, Candice E. Ruck, BSc, Edgardo S. Fortuno, PhD, Kevin Ho, BSc, Pedro Dimitriu, PhD, William W. Mohn, PhD, David P. Speert, MD, Philip J. Cooper, MBBS, PhD, Monika Esser, MD, Tessa Goetghebuer, MD, Arnaud Marchant, MD, PhD, Tobias R. Kollmann, MD, PhD Journal of Allergy and Clinical Immunology Volume 133, Issue 3, Pages 818-826.e4 (March 2014) DOI: 10.1016/j.jaci.2013.09.038 Copyright © 2013 The Authors Terms and Conditions

Fig 1 PCA ordination of the innate immune response for all subjects measured by cytokine secretion in response to PRR agonists. A, The variance in cytokine response (12 dimensions) to all ligands. Each color represents a ligand, while each dot represents 1 subject. B, Eigenvectors show the particular correlations of individual cytokines to the ordination of the PCA in A. Journal of Allergy and Clinical Immunology 2014 133, 818-826.e4DOI: (10.1016/j.jaci.2013.09.038) Copyright © 2013 The Authors Terms and Conditions

Fig 2 Innate immune response to PRR stimulation. PCA ordination of the R848 response is depicted in panel A, LPS in panel B, and PGN in panel C. Each dot represents 1 subject, symbol represents a site, and color represents the stimulation (open [Belgium, Canada, and Ecuador], red [South Africa] for given stimulation). Journal of Allergy and Clinical Immunology 2014 133, 818-826.e4DOI: (10.1016/j.jaci.2013.09.038) Copyright © 2013 The Authors Terms and Conditions

Fig E1 Cytokine production comparison for all 4 sites per cytokine and stimulation. Box-whisker plots, with the median highlighted for each site (the error bars = 90% CI). A, The production of TH1- and TH17-supporting innate cytokines. B, The production of the proinflammatory cytokines and chemokines, as well as the regulatory cytokine IL-10. Journal of Allergy and Clinical Immunology 2014 133, 818-826.e4DOI: (10.1016/j.jaci.2013.09.038) Copyright © 2013 The Authors Terms and Conditions

Fig E1 Cytokine production comparison for all 4 sites per cytokine and stimulation. Box-whisker plots, with the median highlighted for each site (the error bars = 90% CI). A, The production of TH1- and TH17-supporting innate cytokines. B, The production of the proinflammatory cytokines and chemokines, as well as the regulatory cytokine IL-10. Journal of Allergy and Clinical Immunology 2014 133, 818-826.e4DOI: (10.1016/j.jaci.2013.09.038) Copyright © 2013 The Authors Terms and Conditions

Fig E2 Innate immune response to PRR stimulation. PCA ordination of the Poly I:C response is depicted in panel A, PAM in panel B, and MDP in panel C. Each dot represents 1 subject, symbol represents a site, and color represents the stimulation (open [Belgium, Canada, and Ecuador], red [South Africa] for given stimulation). Journal of Allergy and Clinical Immunology 2014 133, 818-826.e4DOI: (10.1016/j.jaci.2013.09.038) Copyright © 2013 The Authors Terms and Conditions

Fig E3 A simplified vaccine schedule for infants at each site. Journal of Allergy and Clinical Immunology 2014 133, 818-826.e4DOI: (10.1016/j.jaci.2013.09.038) Copyright © 2013 The Authors Terms and Conditions