Figure 1 Regulation of hepatic glucose metabolism by the gut, brain and liver Figure 1 | Regulation of hepatic glucose metabolism by the gut, brain and liver. Targeting farnesoid X-activated receptor (FXR) in the gut, the insulin receptor in the brain and S-nitrosylation in the liver in a nutrient-dependent manner alters hepatic glucose production in vivo. ER, endoplasmic reticulum. Lam, T. K. T. (2015) Nutrient and hormone-sensing-dependent regulation Nat. Rev. Endocrinol. doi:10.1038/nrendo.2015.204