Low-Dose Nitric Oxide Inhalation During Initial Reperfusion Enhances Rat Lung Graft Function Moninder S Bhabra, FRCS, David N Hopkinson, MD, Trudi E.

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Low-Dose Nitric Oxide Inhalation During Initial Reperfusion Enhances Rat Lung Graft Function Moninder S Bhabra, FRCS, David N Hopkinson, MD, Trudi E Shaw, Timothy L Hooper, MD The Annals of Thoracic Surgery Volume 63, Issue 2, Pages 339-344 (February 1997) DOI: 10.1016/S0003-4975(96)01019-3

Fig. 1 Reperfusion apparatus. Deoxygenated blood drawn from the inferior vena cava (IVC) of the support animal is delivered to the graft by hydrostatic pressure, generated by a height differential (H) between the two. Graft effluent is returned by a pump (P) to the right atrium (RA) of the support animal. (F = flowmeter; T = pressure transducer; V = ventilator.) The Annals of Thoracic Surgery 1997 63, 339-344DOI: (10.1016/S0003-4975(96)01019-3)

Fig. 2 Partial pressure of oxygen (pO2) in the graft reperfusate over the reperfusion period. There were no statistical differences between groups or within groups over time. Data are shown as mean ± standard error of the mean. The Annals of Thoracic Surgery 1997 63, 339-344DOI: (10.1016/S0003-4975(96)01019-3)

Fig. 3 Partial pressure of oxygen (pO2) in the graft effluent during 1 hour of reperfusion of grafts flushed with University of Wisconsin solution and reperfused immediately (group I) or after 24-hour storage (groups II and III). Group III received 20 ppm inhaled nitric oxide for the first 10 minutes of reperfusion. Data are shown as mean ± standard error of the mean. (∗∗∗p < 0.001 versus group I.) The Annals of Thoracic Surgery 1997 63, 339-344DOI: (10.1016/S0003-4975(96)01019-3)

Fig. 4 Blood flow during 1 hour of reperfusion of grafts flushed with University of Wisconsin solution and reperfused immediately (group I) or after 24-hour storage (groups II and III). Group III received 20 ppm inhaled nitric oxide for the first 10 minutes of reperfusion. Data are shown as mean ± standard error of the mean. (∗∗∗p < 0.001 versus group I.) The Annals of Thoracic Surgery 1997 63, 339-344DOI: (10.1016/S0003-4975(96)01019-3)

Fig. 5 Mean pulmonary artery pressure (MPA) during 1 hour of reperfusion of grafts flushed with University of Wisconsin solution and reperfused immediately (group I) or after 24-hour storage (groups II and III). Group III received 20 ppm inhaled nitric oxide for the first 10 minutes of reperfusion. Data are shown as mean ± standard error of the mean. (∗∗p < 0.01 versus group I.) The Annals of Thoracic Surgery 1997 63, 339-344DOI: (10.1016/S0003-4975(96)01019-3)

Fig. 6 Peak airway pressure (AWP) during 1 hour of reperfusion of grafts flushed with University of Wisconsin solution and reperfused immediately (group I) or after 24-hour storage (groups II and III). Group III received 20 ppm inhaled nitric oxide for the first 10 minutes of reperfusion. Data are shown as mean ± standard error of the mean. (∗p < 0.05 versus group I.) The Annals of Thoracic Surgery 1997 63, 339-344DOI: (10.1016/S0003-4975(96)01019-3)