Knee cartilage thickness measurements using MRI: a 4½-month longitudinal study in the meniscectomized guinea pig model of OA R. Bolbos, M.Sc., H. Benoit-Cattin,

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Presentation transcript:

Knee cartilage thickness measurements using MRI: a 4½-month longitudinal study in the meniscectomized guinea pig model of OA R. Bolbos, M.Sc., H. Benoit-Cattin, Ph.D., J.-B. Langlois, B.Sc., A. Chomel, B.Sc., E. Chereul, Ph.D., C. Odet, Ph.D., P. Pastoureau, Ph.D., M. Janier, M.D., Ph.D., O. Beuf, Ph.D. Osteoarthritis and Cartilage Volume 15, Issue 6, Pages 656-665 (June 2007) DOI: 10.1016/j.joca.2006.12.009 Copyright © 2007 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 Design of the longitudinal study for MRI and histomorphometry assessments; as the consequence of the anesthesia, four MNX (one at D45, two at D90, and one at D135) and four SHAM (one at D90 and three at D135) animals were lost during the follow-up. Osteoarthritis and Cartilage 2007 15, 656-665DOI: (10.1016/j.joca.2006.12.009) Copyright © 2007 Osteoarthritis Research Society International Terms and Conditions

Fig. 2 3D visualization of the active surface deformation. The upper surface fits the femur surface and the lower one the tibia surface in the region of interest. A white line indicates the minimal distance dm between the two surfaces (yellow ball–green ball) corresponding to the minimal distance of the two bone margins of the knee articulation (minimal JSW); Tct (white ball–green ball) is the distance corresponding to the tibial cartilage thickness. Osteoarthritis and Cartilage 2007 15, 656-665DOI: (10.1016/j.joca.2006.12.009) Copyright © 2007 Osteoarthritis Research Society International Terms and Conditions

Fig. 3 Histomorphometric comparison of the two groups, SHAM and MNX: illustrations from day 45 to day 135. Osteoarthritis and Cartilage 2007 15, 656-665DOI: (10.1016/j.joca.2006.12.009) Copyright © 2007 Osteoarthritis Research Society International Terms and Conditions

Fig. 4 Representative images obtained in SHAM guinea pig during follow-up: a, day 15; b, day 45; c, day 90 and d, day 135. Osteoarthritis and Cartilage 2007 15, 656-665DOI: (10.1016/j.joca.2006.12.009) Copyright © 2007 Osteoarthritis Research Society International Terms and Conditions

Fig. 5 Representative images obtained in MNX guinea pig during follow-up: a, day 45; b, day 90; and c, day 135. Osteoarthritis and Cartilage 2007 15, 656-665DOI: (10.1016/j.joca.2006.12.009) Copyright © 2007 Osteoarthritis Research Society International Terms and Conditions

Fig. 6 The MRI longitudinal study: no significant difference was found at D45 between all SHAM and MNX animals; on the contrary, significant differences were found between the groups at D90 (−15.1%, ***P<0.001) and D135 (−23.1%, ***P<0.001), respectively. Osteoarthritis and Cartilage 2007 15, 656-665DOI: (10.1016/j.joca.2006.12.009) Copyright © 2007 Osteoarthritis Research Society International Terms and Conditions

Fig. 7 MRI – histomorphometry data correlations at different time-points during the follow-up; no histomorphometry data are available at D90. Osteoarthritis and Cartilage 2007 15, 656-665DOI: (10.1016/j.joca.2006.12.009) Copyright © 2007 Osteoarthritis Research Society International Terms and Conditions