Clinicopathologic Characteristics of the EGFR Gene Mutation in Non–small Cell Lung Cancer Anne S. Tsao, MD, Xi Ming Tang, MD, PhD, Bradley Sabloff, MD,

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Clinicopathologic Characteristics of the EGFR Gene Mutation in Non–small Cell Lung Cancer Anne S. Tsao, MD, Xi Ming Tang, MD, PhD, Bradley Sabloff, MD, Lianchun Xiao, MS, Hisayuki Shigematsu, MD, Jack Roth, MD, Margaret Spitz, MD, MPH, Waun Ki Hong, MD, Adi Gazdar, MD, Ignacio Wistuba, MD Journal of Thoracic Oncology Volume 1, Issue 3, Pages 231-239 (March 2006) DOI: 10.1016/S1556-0864(15)31573-2 Copyright © 2006 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 1 Microphotographs of two representative lung adenocarcinomas with EGFR mutations (hematoxylin and eosin stained). Panels a (100×) and b (200×) are from a lung adenocarcinoma with a point mutation L858R (T to G) in exon 21 (c) and with invasive acinar and solid patterns (a and b), and without any bronchioloalveolar component in the periphery. Panels d (100×) and e (200×) were obtained from a lung adenocarcinoma having a 15–base pair (746-750) in-frame deletion mutation in exon 19 (f), and with a predominant invasive acinar component (e) and some areas of bronchioloalveolar-like pattern (<20%) in the periphery (d). Journal of Thoracic Oncology 2006 1, 231-239DOI: (10.1016/S1556-0864(15)31573-2) Copyright © 2006 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 2 Two lung tumor cases with EGFR mutations showing invasive adenocarcinoma histologic features (mostly acinar pattern, a and c) and corresponding chest computed tomographic images (b and f). Computed tomographic scans (b and d) show two cases of NSCLC, (b) right upper lobe, (d) right lower lobe, manifesting as ill-defined nodules. Note air bronchograms, which correlate with EGFR mutation status (black arrows). Journal of Thoracic Oncology 2006 1, 231-239DOI: (10.1016/S1556-0864(15)31573-2) Copyright © 2006 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 3 Survival by presence of EGFR and KRAS mutations. Journal of Thoracic Oncology 2006 1, 231-239DOI: (10.1016/S1556-0864(15)31573-2) Copyright © 2006 International Association for the Study of Lung Cancer Terms and Conditions