A Randomized Controlled Trial of Enemas in Combination With Oral Laxative Therapy for Children With Chronic Constipation  Marloes E.J. Bongers, Maartje M. van den Berg, Johannes B. Reitsma, Wieger P. Voskuijl, Marc A. Benninga  Clinical Gastroenterology and Hepatology  Volume 7, Issue 10, Pages 1069-1074 (October 2009) DOI: 10.1016/j.cgh.2009.06.018 Copyright © 2009 AGA Institute Terms and Conditions

Figure 1 Defecation frequency per week for both treatment groups. *Overall test for differences between IG and CG at all 4 time points; results depicted are modeled means by using a linear mixed model. Additional tests for differences between IG and CG at specific time points: #P = .63; §P = .02; ¥P = .46; $P = .02. (Dotted line indicates the lower limit of a normal defecation frequency per week.) Clinical Gastroenterology and Hepatology 2009 7, 1069-1074DOI: (10.1016/j.cgh.2009.06.018) Copyright © 2009 AGA Institute Terms and Conditions

Figure 2 Fecal incontinence frequency <1/week for both treatment groups. *Overall test for differences between IG and CG at all 4 time points by using GEE analysis. Clinical Gastroenterology and Hepatology 2009 7, 1069-1074DOI: (10.1016/j.cgh.2009.06.018) Copyright © 2009 AGA Institute Terms and Conditions

Figure 3 Overall success for both treatment groups. *Overall test for differences between IG and CG at all 4 time points by using GEE analysis. Clinical Gastroenterology and Hepatology 2009 7, 1069-1074DOI: (10.1016/j.cgh.2009.06.018) Copyright © 2009 AGA Institute Terms and Conditions