William G. Kaelin, Peter J. Ratcliffe Molecular Cell

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Presentation transcript:

Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway William G. Kaelin, Peter J. Ratcliffe Molecular Cell Volume 30, Issue 4, Pages 393-402 (May 2008) DOI: 10.1016/j.molcel.2008.04.009 Copyright © 2008 Elsevier Inc. Terms and Conditions

Figure 1 Central Role of PHD Prolyl Hydroxylases and the HIF Transcription Factor in Response to Hypoxia See text for details. Stimulatory interactions are indicated with ↓. Inhibitory interactions are indicated with ⊥. Molecular Cell 2008 30, 393-402DOI: (10.1016/j.molcel.2008.04.009) Copyright © 2008 Elsevier Inc. Terms and Conditions