Development and validation of a noninvasive 2-gene molecular assay for cutaneous melanoma Pedram Gerami, MD, Zuxu Yao, PhD, David Polsky, MD, PhD, Burkhard.

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Presentation transcript:

Development and validation of a noninvasive 2-gene molecular assay for cutaneous melanoma Pedram Gerami, MD, Zuxu Yao, PhD, David Polsky, MD, PhD, Burkhard Jansen, MD, Klaus Busam, MD, Jonhan Ho, MD, Mary Martini, MD, Laura K. Ferris, MD, PhD Journal of the American Academy of Dermatology Volume 76, Issue 1, Pages 114-120.e2 (January 2017) DOI: 10.1016/j.jaad.2016.07.038 Copyright © 2016 American Academy of Dermatology, Inc. Terms and Conditions

Journal of the American Academy of Dermatology 2017 76, 114-120 Journal of the American Academy of Dermatology 2017 76, 114-120.e2DOI: (10.1016/j.jaad.2016.07.038) Copyright © 2016 American Academy of Dermatology, Inc. Terms and Conditions

Fig 1 Noninvasive adhesive patch skin biopsy. Journal of the American Academy of Dermatology 2017 76, 114-120.e2DOI: (10.1016/j.jaad.2016.07.038) Copyright © 2016 American Academy of Dermatology, Inc. Terms and Conditions

Fig 2 Receiver operating characteristic curves demonstrating the PLA's potential to differentiate primary cutaneous melanoma samples from nonmelanoma samples (primarily atypical nevi) based on LINC00518 and/or preferentially expressed antigen in melanoma detection. AUC, Area under the curve. Journal of the American Academy of Dermatology 2017 76, 114-120.e2DOI: (10.1016/j.jaad.2016.07.038) Copyright © 2016 American Academy of Dermatology, Inc. Terms and Conditions

Fig 3 Comparison of LINC00518 (LINC), actin B (ACTB) and preferentially expressed antigen in melanoma (PRAME) gene expression in patient-derived melanoma xenografts (PDX) compared with nonmelanoma xenografts (A), and in adhesive patch samples of primary cutaneous melanomas processed with the PDX samples as controls (B). Ct, Cycle threshold. Journal of the American Academy of Dermatology 2017 76, 114-120.e2DOI: (10.1016/j.jaad.2016.07.038) Copyright © 2016 American Academy of Dermatology, Inc. Terms and Conditions