Acute effects of viral respiratory tract infections on sputum bacterial density during CF pulmonary exacerbations  Melanie Chin, Maya De Zoysa, Robert Slinger, Ena Gaudet, Katherine L. Vandemheen, Francis Chan, Lucie Hyde, Thien-Fah Mah, Wendy Ferris, Ranjeeta Mallick, Shawn D. Aaron  Journal of Cystic Fibrosis  Volume 14, Issue 4, Pages 482-489 (July 2015) DOI: 10.1016/j.jcf.2014.11.009 Copyright © 2014 European Cystic Fibrosis Society. Terms and Conditions

Fig. 1 Comparison of signs & symptoms of CF pulmonary exacerbations in patients with viral and non-viral exacerbations. Blue columns indicate patients with viral exacerbations, and red columns indicate patients with non-viral exacerbations. * indicates exacerbation criteria where the difference in the two groups was statistically significant. Those patients with virus-triggered exacerbations experienced significantly less dyspnea (p=0.009), and were less likely to have a decreased exercise tolerance (p=0.0195) or new findings on respiratory exam (p=0.0147). Journal of Cystic Fibrosis 2015 14, 482-489DOI: (10.1016/j.jcf.2014.11.009) Copyright © 2014 European Cystic Fibrosis Society. Terms and Conditions

Fig. 2 Comparison of P. aeruginosa colony counts in sputum during stable, exacerbation, and post-exacerbation assessments. The black circles represent individual sputum samples at exacerbation while mean colony counts at each time point are shown in red circles. Journal of Cystic Fibrosis 2015 14, 482-489DOI: (10.1016/j.jcf.2014.11.009) Copyright © 2014 European Cystic Fibrosis Society. Terms and Conditions

Fig. 3 Comparison of the change in P. aeruginosa colony counts from stable to exacerbation states, in viral and non-viral exacerbations (reported as log10CFU/ml). Mean change (red bar) for non-viral exacerbations was 0.30log10CFU/ml (95% CI −0.52 to 1.11); mean change for viral exacerbations was −0.29log10CFU/ml (95% CI −0.90 to 0.33). Journal of Cystic Fibrosis 2015 14, 482-489DOI: (10.1016/j.jcf.2014.11.009) Copyright © 2014 European Cystic Fibrosis Society. Terms and Conditions

Fig. 4 Comparison of the change in P. aeruginosa PCR cycle threshold from stable to exacerbation states, in viral and non-viral exacerbations. Mean change (red bar) for non-viral exacerbations was 0.22cycles (95% CI −1.06 to 1.50); mean change for viral exacerbations was −0.92cycles (95% CI −2.64 to 0.80). Journal of Cystic Fibrosis 2015 14, 482-489DOI: (10.1016/j.jcf.2014.11.009) Copyright © 2014 European Cystic Fibrosis Society. Terms and Conditions