Pharmacodynamic comparison of linezolid, teicoplanin and vancomycin against clinical isolates of Staphylococcus aureus and coagulase-negative staphylococci.

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Pharmacodynamic comparison of linezolid, teicoplanin and vancomycin against clinical isolates of Staphylococcus aureus and coagulase-negative staphylococci collected from hospitals in Brazil J.L. Kuti, C.R.V. Kiffer, C.M.F. Mendes, D.P. Nicolau Clinical Microbiology and Infection Volume 14, Issue 2, Pages 116-123 (February 2008) DOI: 10.1111/j.1469-0691.2007.01885.x Copyright © 2008 European Society of Clinical Infectious Diseases Terms and Conditions

FIG. 1 Probability of linezolid 600 mg every 12 h achieving a total AUC/MIC >82.9 at increasing MIC dilutions. Clinical Microbiology and Infection 2008 14, 116-123DOI: (10.1111/j.1469-0691.2007.01885.x) Copyright © 2008 European Society of Clinical Infectious Diseases Terms and Conditions

FIG. 2 Probability of teicoplanin achieving a total AUC/MIC >345 at increasing MIC dilutions with: (a) 400 mg every 24 h; (b) 800 mg every 24 h. Clinical Microbiology and Infection 2008 14, 116-123DOI: (10.1111/j.1469-0691.2007.01885.x) Copyright © 2008 European Society of Clinical Infectious Diseases Terms and Conditions

FIG. 3 Probability of vancomycin achieving a total AUC/MIC >345 or a free AUC/MIC >180 at increasing MIC dilutions with: (a) 1000 mg every 12 h; (b) 1000 mg every 8 h. Total drug probability of target attainment (PTA) is represented by closed circles, and free drug PTA by open circles. Clinical Microbiology and Infection 2008 14, 116-123DOI: (10.1111/j.1469-0691.2007.01885.x) Copyright © 2008 European Society of Clinical Infectious Diseases Terms and Conditions

FIG. 4 Sensitivity analysis for cumulative fraction of responses (CFR) against methicillin-susceptible and -resistant Staphylococcus aureus populations. For each antibiotic regimen, results for methicillin-susceptible isolates are shown in open boxes, and those for methicillin-resistant isolates in shaded boxes. Each box represents the range of CFR attained at the highest and lowest pharmacodynamic targets. The asterisk represents the CFR at the initial pharmacodynamic target. Clinical Microbiology and Infection 2008 14, 116-123DOI: (10.1111/j.1469-0691.2007.01885.x) Copyright © 2008 European Society of Clinical Infectious Diseases Terms and Conditions