Blood Pressure and Outcomes in Very Old Hypertensive Coronary Artery Disease Patients: An INVEST Substudy Scott J. Denardo, MD, Yan Gong, PhD, Wilmer.

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Blood Pressure and Outcomes in Very Old Hypertensive Coronary Artery Disease Patients: An INVEST Substudy Scott J. Denardo, MD, Yan Gong, PhD, Wilmer W. Nichols, PhD, Franz H. Messerli, MD, Anthony A. Bavry, MD, MPH, Rhonda M. Cooper-DeHoff, PharmD, Eileen M. Handberg, PhD, Annette Champion, MBA, Carl J. Pepine, MD The American Journal of Medicine Volume 123, Issue 8, Pages 719-726 (August 2010) DOI: 10.1016/j.amjmed.2010.02.014 Copyright © 2010 Terms and Conditions

Figure 1 Systolic blood pressure (A), diastolic blood pressure (B), and pulse pressure (C) as a function of age (in 10-year increments) and time. The American Journal of Medicine 2010 123, 719-726DOI: (10.1016/j.amjmed.2010.02.014) Copyright © 2010 Terms and Conditions

Figure 2 Primary and secondary outcomes as a function of age (in 10-year increments). The American Journal of Medicine 2010 123, 719-726DOI: (10.1016/j.amjmed.2010.02.014) Copyright © 2010 Terms and Conditions

Figure 3 Fatal myocardial infarction and stroke as a function of age (in 10-year increments). The American Journal of Medicine 2010 123, 719-726DOI: (10.1016/j.amjmed.2010.02.014) Copyright © 2010 Terms and Conditions

Figure 4 Primary and secondary outcomes as a function of age (in 10-year increments) based upon treatment strategy. The American Journal of Medicine 2010 123, 719-726DOI: (10.1016/j.amjmed.2010.02.014) Copyright © 2010 Terms and Conditions

Figure 5 Adjusted hazard ratio as a function of age (in 10-year increments), systolic and diastolic blood pressure. Reference systolic and diastolic blood pressure for hazard ratio: 140 and 90 mm Hg, respectively. Blood pressures are the on-treatment average of all postbaseline recordings. The quadratic terms for both systolic and diastolic blood pressures were statistically significant in all age groups (all P <.001, except for diastolic blood pressure in 60-70-year-olds for whom P=0.006). The adjustment was based upon sex, race, history of myocardial infarction, heart failure, peripheral vascular disease, diabetes, stroke/transient ischemic attack, renal insufficiency, and smoking. The American Journal of Medicine 2010 123, 719-726DOI: (10.1016/j.amjmed.2010.02.014) Copyright © 2010 Terms and Conditions