Expression of the inflammatory regulator A20 correlates with lung function in patients with cystic fibrosis Catriona Kelly, Mark T. Williams, J. Stuart.

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Presentation transcript:

Expression of the inflammatory regulator A20 correlates with lung function in patients with cystic fibrosis Catriona Kelly, Mark T. Williams, J. Stuart Elborn, Madeleine Ennis, Bettina C. Schock Journal of Cystic Fibrosis Volume 12, Issue 4, Pages 411-415 (July 2013) DOI: 10.1016/j.jcf.2012.10.009 Copyright © 2012 European Cystic Fibrosis Society. Terms and Conditions

Fig. 1 The effect of CFTR and genotype on A20 and TAX1BP1 mRNA expression. The basal expression of A20 (A) and TAX1BP1 (B) was assessed by qPCR in 16HBE14o- cells treated with siRNA against CFTR. Data are presented as mean±SEM with n=3. ***p<0.001 compared with scrambled siRNA. The effect of different CF genotypes (R117H/F508del and F508del/F508del) on basal A20 (C) and TAX1BP1 (D) mRNA expression was determined by qPCR. Basal expression was expressed relative to Jurkat cells, which acted as an internal calibrator for all experiments. Furthermore, the mRNA expression of LPS-induced A20 (E) and TAX1BP1 (F) was also determined by qPCR. Expression was calculated after 24h simulation with LPS and data are presented as mean±SEM with n=6–8 as indicated in the figure. *p<0.05, ***p<0.001 between groups as indicated in the figure. Journal of Cystic Fibrosis 2013 12, 411-415DOI: (10.1016/j.jcf.2012.10.009) Copyright © 2012 European Cystic Fibrosis Society. Terms and Conditions

Fig. 2 Relationship between A20, TAX1BP1, p65 and lung function in different CF genotypes. The effect of different CF genotypes (R117H/F508del and F508del/F508del) on LPS-induced p65 (A) expression was determined by qPCR. Expression was calculated after 24h simulation with LPS and data are presented as mean±SEM with n=6–8 as indicated in the figure. *p<0.05, **p<0.01 between groups as indicated in the figure. The relationship between p65 and A20 (B) or TAX1BP1 (C) expression was assessed by Spearman rank test. Significant correlations are indicated in the figure (r value). The relationship between FEV1 and A20 (D) or TAX1BP1 (E) expression was assessed by Spearman rank test. Significant correlations are indicated in the figure (r value). Journal of Cystic Fibrosis 2013 12, 411-415DOI: (10.1016/j.jcf.2012.10.009) Copyright © 2012 European Cystic Fibrosis Society. Terms and Conditions