Tracking the naturally occurring mutations across the full-length genome of hepatitis B virus of genotype D in different phases of chronic e-antigen-negative.

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Tracking the naturally occurring mutations across the full-length genome of hepatitis B virus of genotype D in different phases of chronic e-antigen-negative infection S. Ghosh, R.K. Mondal, P. Banerjee, M. Nandi, S. Sarkar, K. Das, A. Santra, S. Banerjee, A. Chowdhury, S. Datta Clinical Microbiology and Infection Volume 18, Issue 10, Pages E412-E418 (October 2012) DOI: 10.1111/j.1469-0691.2012.03975.x Copyright © 2012 European Society of Clinical Infectious Diseases Terms and Conditions

FIG. 1. Phylogenetic tree analysis of full-length sequences of 60 HBV isolates from chronic HBeAg-negative patients along with 50 reference sequences of HBV belonging to different genotypes (A–J) derived from GenBank, including three sequences of HBV from non-human primates. HBV sequences from GenBank are indicated by their genotypes followed by accession numbers and country of origin. The sequences determined in the study are given by the isolate number followed by the clinical status of the patient (IC/CHB/LC) from whom it was derived. The phylogenetic tree was built using the Jukes Cantor and neighbour joining (NJ) method by MEGA software version5 and bootstrap resampling and reconstruction were carried out 5000 times. Clinical Microbiology and Infection 2012 18, E412-E418DOI: (10.1111/j.1469-0691.2012.03975.x) Copyright © 2012 European Society of Clinical Infectious Diseases Terms and Conditions