Combinatorial Enzymatic Synthesis of Heparan Sulfate

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Presentation transcript:

Combinatorial Enzymatic Synthesis of Heparan Sulfate Robert J. Linhardt, Jin-Hwan Kim Chemistry & Biology Volume 14, Issue 9, Pages 972-973 (September 2007) DOI: 10.1016/j.chembiol.2007.09.002 Copyright © 2007 Elsevier Ltd Terms and Conditions

Figure 1 Chemoenzymatic Synthetic Scheme of Polysaccharide Variants of Heparan Sulfate from E. coli Heparosan NDST is N-deacetylase N-sulfotransferase; OSTs are O-sulfotransferases; and Epi is C5 epimerase catalyzing the conversion of glucuronic acid to iduronic acid. PAPS is required as a sulfate donor for NDST and OST enzymes. Chemistry & Biology 2007 14, 972-973DOI: (10.1016/j.chembiol.2007.09.002) Copyright © 2007 Elsevier Ltd Terms and Conditions

Figure 2 Antithrombin Binding of Oligosaccharides and Full-Length Heparan Sulfate Polysaccharides as a Function of the Number of Saccharide Residues Chemistry & Biology 2007 14, 972-973DOI: (10.1016/j.chembiol.2007.09.002) Copyright © 2007 Elsevier Ltd Terms and Conditions