Improved monofollicular ovulation in anovulatory or oligo-ovulatory women after a low- dose step-up protocol with weekly increments of 25 international.

Slides:



Advertisements
Similar presentations
The effectiveness of gonadotropin-releasing hormone antagonist in poor ovarian responders undergoing in vitro fertilization: a systematic review and meta-analysis 
Advertisements

Edward G. Hughes, M.B., F.R.C.S.(C.), Deirdre DeJean, M.Sc. 
Fertility and Sterility  Volume 97, Issue 3, Pages (March 2012)
The relative effects of hormones and relationship factors on sexual function of women through the natural menopausal transition  Lorraine Dennerstein,
Fernando Zegers-Hochschild, M.D.  Fertility and Sterility 
Michael M. Alper, M.D.  Fertility and Sterility 
Administration of a gonadotropin-releasing hormone antagonist during the 3 days before the initiation of the in vitro fertilization/intracytoplasmic sperm.
Randomized, multicenter, double-blind, placebo-controlled trial to evaluate the efficacy and safety of synthetic conjugated estrogens B for the treatment.
Possible metformin effect on adrenal androgens during pretreatment and IVF cycle in women with polycystic ovary syndrome  Sigrun B. Kjøtrød, M.D., Arne.
Hepatitis and reproduction
Growth rates of ovarian follicles during natural menstrual cycles, oral contraception cycles, and ovarian stimulation cycles  Angela R. Baerwald, Ph.D.,
Cem Atabekoglu, M. D. , Murat Sonmezer, M. D. , Sinan Özkavukcu, M. D
Ethnicity as a determinant of ovarian reserve: differences in ovarian aging between Spanish and Indian women  Carlos Iglesias, M.D., Manish Banker, M.D.,
Can an educational DVD improve the acceptability of elective single embryo transfer? A randomized controlled study  Nicole Hope, M.B., B.S., Hon., Luk.
Medical treatment of ectopic pregnancy: a committee opinion
The role of antimullerian hormone in prediction of outcome after IVF: comparison with the antral follicle count  Simone L. Broer, B.Sc., Ben Willem J.
Hakan Cakmak, M. D. , Audra Katz, R. N. , Marcelle I. Cedars, M. D
Anti-Müllerian hormone: correlation of early follicular, ovulatory and midluteal levels with ovarian response and cycle outcome in intracytoplasmic sperm.
Grant D.E. McWilliams, D.O., John L. Frattarelli, M.D. 
How old is too old? Challenges faced by clinicians concerning age cutoffs for patients undergoing in vitro fertilization  Robert L. Klitzman, M.D.  Fertility.
The role of steroid hormone supplementation in non–assisted reproductive technology treatments for unexplained infertility  Alexander M. Quaas, M.D.,
A Markov model of the cost-effectiveness of human-derived follicle-stimulating hormone (FSH) versus recombinant FSH using comparative clinical trial data 
Martin D. Keltz, M. D. , Josh C. Skorupski, M. D. , Katrina Bradley, M
Oocyte cryopreservation
Do anti-mullerian hormone levels predict ovarian reserve in SLE patients presenting for hematopoietic stem cell transplant?  H. Browne, A. Armstrong,
Deleterious effect of tobacco on IVF outcome and ovarian reserve as reflected by serum anti mullerian hormone (AMH)  P. Barriere, T. Freour, D. Masson,
Angela R. Baerwald, Ph. D. , Olufemi A. Olatunbosun, M. D. , Roger A
Establishing a human chorionic gonadotropin cutoff to guide methotrexate treatment of ectopic pregnancy: a systematic review  Seema Menon, M.D., John.
Robert F. Casper, M.D.  Fertility and Sterility 
Impact of luteal phase support on pregnancy rates in intrauterine insemination cycles: a prospective randomized study  Ahmet Erdem, M.D., Mehmet Erdem,
Anastrozole vs. clomiphene citrate in infertile women with ovulatory dysfunction: a phase II, randomized, dose-finding study  Donald Tredway, M.D., Ph.D.,
Influence of acupuncture stimulation on pregnancy rates for women undergoing embryo transfer  Caroline Smith, Ph.D., Meaghan Coyle, B.Hlth.Sc. (Acup.),
Ovarian response and follicular development for single-dose and multiple-dose protocols for gonadotropin-releasing hormone antagonist administration 
Evaluation of the relationship between plasma concentrations of en- and zuclomiphene and induction of ovulation in anovulatory women being treated with.
A comparison of three downregulation approaches for poor responders undergoing in vitro fertilization  Laura Detti, M.D., Daniel B. Williams, M.D., Jared.
Ultrashort flare gonadotropin-releasing hormone (GnRH) agonist/GnRH antagonist protocol: a valuable tool in the armamentarium of ovulation induction for.
The effectiveness of gonadotropin-releasing hormone antagonist in poor ovarian responders undergoing in vitro fertilization: a systematic review and meta-analysis 
Patients with severe ovarian hyperstimulation syndrome can be managed safely with aggressive outpatient transvaginal paracentesis  Laura P. Smith, M.D.,
Duphaston and human menopausal gonadotropin protocol in normally ovulatory women undergoing controlled ovarian hyperstimulation during in vitro fertilization/intracytoplasmic.
Tomer Singer, M. D. , David H. Barad, M. D. , M. S
Management of tubal ectopic pregnancy: methotrexate and salpingostomy are preferred to preserve fertility  Stephanie Beall, M.D., Ph.D., Alan H. DeCherney,
Clomiphene citrate at 50: the dawning of assisted reproduction
Cervical mucus status can be accurately estimated by transvaginal ultrasound during fertility evaluation  Igal Wolman, M.D., Tamar Birenbaum Gal, M.D.,
Treatment of Ovarian Hyperstimulation Syndrome Utilizing a Dopamine Agonist and Gonadotropin Releasing Hormone antagonist  N. Rollene, M. Amols, S. Hudson,
Akanksha Mehta, M.D., Darius A. Paduch, M.D., Ph.D. 
Effect of letrozole at 2. 5 mg or 5
Lower apoptosis rate in human cumulus cells after administration of recombinant luteinizing hormone to women undergoing ovarian stimulation for in vitro.
Birth outcomes after spontaneous or assisted conception among infertile Australian women aged 28 to 36 years: a prospective, population-based study  Danielle.
Increased secretion of amylin in women with polycystic ovary syndrome
Efficacy and safety of human chorionic gonadotropin for follicular phase stimulation in assisted reproduction: a systematic review and meta-analysis 
Fertility and Sterility
Aviad Cohen, M. D. , Guy Bibi, M. D. , Benny Almog, M. D
Treatment of ovarian hyperstimulation syndrome using a dopamine agonist and gonadotropin releasing hormone antagonist: a case series  Nanette L. Rollene,
Effectiveness of highly purified human menopausal gonadotropin vs
Pregnancy outcome in infertile patients with polycystic ovary syndrome who were treated with metformin  Samuel S. Thatcher, M.D., Ph.D., Elizabeth M.
Efficacy of luteinizing hormone activity in patients undergoing in vitro fertilization and treated only with low-dose recombinant choriogonadotropin alfa.
Reducing the dose of human chorionic gonadotropin in high responders does not affect the outcomes of in vitro fertilization  David W. Schmidt, M.D.,,
Fertility and Sterility: an evaluation
Moderately elevated levels of basal follicle-stimulating hormone in young patients predict low ovarian response, but should not be used to disqualify.
Use of Utrogestan during controlled ovarian hyperstimulation in normally ovulating women undergoing in vitro fertilization or intracytoplasmic sperm injection.
Current evaluation of amenorrhea
A woman with premature ovarian failure induced by Tripterygium wilfordii Hook.f. gives birth to a healthy child  Xin Chen, M.D., M.Sc., Shi-ling Chen,
David H. Barad, M.D., M.S., Norbert Gleicher, M.D. 
Comparison of the Ovulation Induction and Hormone Profile Between Anastrozole and Clomiphene Citrate in Women With Infertility  H. Wu, P. Chen, N.M. Wang,
In vitro sildenafil citrate use as a sperm motility stimulant
Anastrozole single-dose protocol in women with oligo- or anovulatory infertility: results of a randomized phase II dose–response study  Donald Tredway,
Performance of basal follicle-stimulating hormone and patient's age in the prediction of poor ovarian response and IVF outcome of women who developed.
Incidence and prediction of ovarian hyperstimulation syndrome in women undergoing gonadotropin-releasing hormone antagonist in vitro fertilization cycles 
Progesterone level and progesterone/estradiol ratio on the day of hCG administration: detrimental cutoff levels and new treatment strategy  Eman A. Elgindy,
A novel “delayed start” protocol with gonadotropin-releasing hormone antagonist improves outcomes in poor responders  Hakan Cakmak, M.D., Nam D. Tran,
Presentation transcript:

Improved monofollicular ovulation in anovulatory or oligo-ovulatory women after a low- dose step-up protocol with weekly increments of 25 international units of follicle- stimulating hormone  A. Leader, M.D.  Fertility and Sterility  Volume 85, Issue 6, Pages 1766-1773 (June 2006) DOI: 10.1016/j.fertnstert.2005.11.049 Copyright © 2006 American Society for Reproductive Medicine Terms and Conditions

FIGURE 1 Results for primary efficacy (A) and efficiency (B) outcome measures (all treated subjects). Leader. Improved monofollicular ovulation. Fertil Steril 2006. Fertility and Sterility 2006 85, 1766-1773DOI: (10.1016/j.fertnstert.2005.11.049) Copyright © 2006 American Society for Reproductive Medicine Terms and Conditions

FIGURE 2 Number and size of follicles on day of hCG administration or 1–3 days earlier. (A) All subjects who received hCG treatment (n = 124) and (B) all patients who received hCG but did not convert to IVF (n = 118). Leader. Improved monofollicular ovulation. Fertil Steril 2006. Fertility and Sterility 2006 85, 1766-1773DOI: (10.1016/j.fertnstert.2005.11.049) Copyright © 2006 American Society for Reproductive Medicine Terms and Conditions

FIGURE 3 Cancellation rate due to ovarian hyperresponse by treatment period (all-subjects-treated). Leader. Improved monofollicular ovulation. Fertil Steril 2006. Fertility and Sterility 2006 85, 1766-1773DOI: (10.1016/j.fertnstert.2005.11.049) Copyright © 2006 American Society for Reproductive Medicine Terms and Conditions