Volume 122, Issue 2, Pages 281-289 (February 2002) Excess alcohol greatly increases the prevalence of cirrhosis in hereditary hemochromatosis  Linda M. Fletcher, Jeannette L. Dixon, David M. Purdie, Lawrie W. Powell, Darrell H.G. Crawford  Gastroenterology  Volume 122, Issue 2, Pages 281-289 (February 2002) DOI: 10.1053/gast.2002.30992 Copyright © 2002 American Gastroenterological Association Terms and Conditions

Fig. 1 Distribution of study population of hereditary hemochromatosis subjects in relation to alcohol consumption and liver blood tests. Gastroenterology 2002 122, 281-289DOI: (10.1053/gast.2002.30992) Copyright © 2002 American Gastroenterological Association Terms and Conditions

Fig. 2 Relationship between HIC (mean ± SD) and fibrosis in those subjects who consume less than 60 g alcohol per day (□) compared with those who drink greater than or equal to 60 g per day (▩). Numbers in parentheses represent numbers of subjects in each group. *P value between groups with no fibrosis vs. severe/cirrhosis; mild/mod fibrosis vs. severe/cirrhosis in subjects with alcohol consumption <60 g/day (□). **P value comparing patients with severe fibrosis/cirrhosis who consume <60 g/day and those with severe fibrosis/cirrhosis who consume ≥60 g/day. Gastroenterology 2002 122, 281-289DOI: (10.1053/gast.2002.30992) Copyright © 2002 American Gastroenterological Association Terms and Conditions

Fig. 3 Relationship between HIC and fibrosis in (A) all subjects who consume less than 60 g alcohol/day (n = 170) and (B) those subjects who drink equal to or more than 60 g per day (n = 36). Numbers in parentheses represent numbers of subjects in each group. Horizontal bars represent mean HIC. Gastroenterology 2002 122, 281-289DOI: (10.1053/gast.2002.30992) Copyright © 2002 American Gastroenterological Association Terms and Conditions

Fig. 4 Relationship between HIC and fibrosis in (A) subjects who drink less than 60 g per day and who have normal liver blood tests (LBT) (n = 117) and (B) those who have abnormal LBT (n = 53). Numbers in parentheses represent numbers of subjects in each group. Horizontal bars represent mean HIC. Gastroenterology 2002 122, 281-289DOI: (10.1053/gast.2002.30992) Copyright © 2002 American Gastroenterological Association Terms and Conditions

Fig. 5 Relationship between HII and fibrosis in (A) all subjects who consume less than 60 g alcohol per day (n = 170) and (B) those subjects who drink more than 60 g per day (n = 36). Numbers in parentheses represent numbers of subjects in each group. Horizontal bars represent mean HII. Gastroenterology 2002 122, 281-289DOI: (10.1053/gast.2002.30992) Copyright © 2002 American Gastroenterological Association Terms and Conditions

Fig. 6 The prevalence of abnormal liver blood tests, steatosis, fibrosis, cirrhosis, and HCC in relation to alcohol consumption in hereditary hemochromatosis (□, alcohol consumption <60 g per day; ▩, alcohol consumption ≥60 g per day). Numbers refer to number of subjects in each group. AbnLBT, abnormal liver blood tests; HCC, hepatocellular carcinoma. Gastroenterology 2002 122, 281-289DOI: (10.1053/gast.2002.30992) Copyright © 2002 American Gastroenterological Association Terms and Conditions