SS-31 reduces inflammation after acute renal ischemia.

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Volume 62, Pages S12-S22 (December 2002)

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SS-31 reduces inflammation after acute renal ischemia. SS-31 reduces inflammation after acute renal ischemia. Rats were treated with SS-31 (2 mg/kg per day) or saline for 1.5 months starting 1 month after acute ischemia. (A) The number of CD68+ macrophages per glomerulus at various times after ischemia. The number shown reflects the average determined from ten glomeruli per sample and averaged. Data shown as mean±SEM; n=4/group; ***P<0.001. (B) Representative Western blot and densitometric analysis of TNF-α expression in renal cortical tissue at various times after acute ischemia. Data shown as mean±SEM; n=4/group; **P<0.01; ***P<0.001. (C) Representative Western blot and densitometric analysis of IL-18 expression in renal cortical tissue at various times after acute ischemia. Data shown as mean±SEM; n=4/group; **P<0.01; ***P<0.001. (D) Representative Western blot and densitometric analysis of IL-1β expression in renal cortical tissue at various times after acute ischemia in saline and SS-31-treated rats, versus age-matched controls. Data shown as mean±SEM; n=4/group; **P<0.01. (See Supplemental Figure 1 for all Western blots). Hazel H. Szeto et al. JASN 2017;28:1437-1449 ©2017 by American Society of Nephrology