Evolution of a chemosensitive core-binding factor AML into an aggressive leukemia with eosinophilic differentiation by Wenbin Xiao, Mariko Yabe, Michael.

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Evolution of a chemosensitive core-binding factor AML into an aggressive leukemia with eosinophilic differentiation by Wenbin Xiao, Mariko Yabe, Michael Offin, Pallavi Khattar, Jeeyeon Baik, Ryan J. Daley, Jeremy J. Pappacena, Mikhail Roshal, Yanming Zhang, Martin S. Tallman, and Sheng F. Cai BloodAdv Volume 2(13):1517-1521 July 10, 2018 © 2018 by The American Society of Hematology

Wenbin Xiao et al. Blood Adv 2018;2:1517-1521 © 2018 by The American Society of Hematology

Histology of hypereosinophilic syndrome in AML Histology of hypereosinophilic syndrome in AML. (A) Marked eosinophilia in the bone marrow at the last relapse (original magnification ×40; inset ×400; hematoxylin and eosin stain). Histology of hypereosinophilic syndrome in AML. (A) Marked eosinophilia in the bone marrow at the last relapse (original magnification ×40; inset ×400; hematoxylin and eosin stain). Eosinophilic infiltrate in (B) lymph node, (C) adrenal medulla (inset: CD34 immunostain), and (D) liver at autopsy. Original magnification by ×400, hematoxylin and eosin stain, except as noted. Wenbin Xiao et al. Blood Adv 2018;2:1517-1521 © 2018 by The American Society of Hematology

Detection of KRASG12D mutation and inv(16) in sorted blasts and eosinophils. Detection of KRASG12Dmutation and inv(16) in sorted blasts and eosinophils. (A) Dot plot of bone marrow cells (yellow: eosinophils; red: blasts; blue: lymphocytes; pink: monocytes; green: neutrophils). (B) Sorted blasts (CD45dimCD34+CD15−CD117+SSClo). (C) Sorted eosinophils (CD45+CD34−CD117−CD15+SSChi). FISH studies using CBFB break-apart probes (Abbott Molecular, Des Plaines, IL) showing a split signal pattern of CBFB probes (ie, inv(16)), in (D) sorted blasts and in (E) eosinophils. Detection of KRASG12D in (F) sorted blasts, (G) eosinophils, and (H) FFPE adrenal tissue by ddPCR. Blue dots represent mutant droplets; green dots represent wild-type droplets, and red or gray dots represent empty droplets. SSC-H, side-scatter height. Wenbin Xiao et al. Blood Adv 2018;2:1517-1521 © 2018 by The American Society of Hematology