Targeting β-catenin in CML: Leukemia Stem Cells Beware!

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Targeting β-catenin in CML: Leukemia Stem Cells Beware! Maria Kleppe, Ross L. Levine Cell Stem Cell Volume 10, Issue 4, Pages 351-353 (April 2012) DOI: 10.1016/j.stem.2012.03.006 Copyright © 2012 Elsevier Inc. Terms and Conditions

Figure 1 Treatment Landscape for CML Patients The figure denotes current and novel therapeutic options for CML patients. Imatinib therapy reduces leukemia bulk cells, but does not deplete leukemia stem cells (LSCs). By contrast, inhibition of Wnt signaling inhibits LSCs but not bulk leukemia cells. For patients with resistance alleles, second generation TKIs lead to responses, but again do not eradicate LSCs. By contrast, combined TKI treatment and Wnt pathway inhibition leads to inhibition of LSCs and bulk leukemic cells and to potential eradication of the CML clone. Cell Stem Cell 2012 10, 351-353DOI: (10.1016/j.stem.2012.03.006) Copyright © 2012 Elsevier Inc. Terms and Conditions