Recanalization of arterial thrombus, and inhibition with β-radiation in a new murine carotid occlusion model: mRNA expression of angiopoietins, metalloproteinases,

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Recanalization of arterial thrombus, and inhibition with β-radiation in a new murine carotid occlusion model: mRNA expression of angiopoietins, metalloproteinases, and their inhibitors Jean Raymond, MD, Vickie Lebel, MSc, Christelle Ogoudikpe, MSc, Annick Metcalfe, MSc, Miguel Chagnon, MSc, Olivier Robledo, PhD Journal of Vascular Surgery Volume 40, Issue 6, Pages 1190-1198 (December 2004) DOI: 10.1016/j.jvs.2004.09.023 Copyright © 2004 The Society for Vascular Surgery Terms and Conditions

Fig 1 Coil occlusion model and angiographic results. a, Intraoperative photograph shows endoluminal implantation of platinum coil (arrowheads). b, Transmyocardial angiogram of normal carotid artery is shown for comparison. Transmyocardial angiograms 2 days (c, e) and 15 days (d, f) after surgical implantation of not radioactive (c, d) or radioactive (e, f) platinum coils show occlusion on day 2 with both types of coils (c, e). Artery remains occluded at 15 days when coil is radioactive (arrows in f), but recanalizes when coil is not radioactive (d). Journal of Vascular Surgery 2004 40, 1190-1198DOI: (10.1016/j.jvs.2004.09.023) Copyright © 2004 The Society for Vascular Surgery Terms and Conditions

Fig 2 Coil occlusion of carotid artery: pathologic findings. Axial sections of normal carotid artery (a) and of carotid artery 2 days (b) or 15 days (c, d) after coil occlusion (arrow in b). Artery is recanalized (asterisks in c) when coil was not radioactive, whereas lumen was completely filled with conjunctive tissue (d) when coil was radioactive. c and d, Images are of sections immediately above coil. (a, b, Hematoxylin-eosin stain; c, d, Movat pentachrome stain; original magnification ×100 [a] or ×50 [b-d]). Journal of Vascular Surgery 2004 40, 1190-1198DOI: (10.1016/j.jvs.2004.09.023) Copyright © 2004 The Society for Vascular Surgery Terms and Conditions

Fig 3 Gene expression of endothelial markers. Reverse transcriptase–polymerase chain reaction analysis of carotid arteries implanted with radioactive coils (white bars) or nonradioactive coils (black bars). Results at 2, 6, or 15 days are expressed as ratio relative to expression found in normal carotid arteries (control arteries [CTL], gray bars). Note decreased expression of most genes at 2 and 6 days with both types of coils. vWF, von Willebrand factor; PECAM, platelet endothelial cell adhesion molecule; VCAM-1, vascular cell adhesion molecule-1; VE-CAD, vascular endothelium cadherin; eNOS, endothelial nitric oxide synthase. Journal of Vascular Surgery 2004 40, 1190-1198DOI: (10.1016/j.jvs.2004.09.023) Copyright © 2004 The Society for Vascular Surgery Terms and Conditions

Fig 4 Gene expression of matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs (TIMPs). Reverse transcriptase–polymerase chain rection analysis of MMP and TIMP expression in carotid arteries implanted with radioactive coils (white bars) or nonradioactive coils (black bars). Results at 2, 6, or 15 days are expressed as ratio relative to expression found in normal carotid arteries (control arteries [CTL], gray bars). Note significant differences in MMP-9 (P = .003) and TIMP-4 (P = .001) expression between radioactive and nonradioactive coils. Journal of Vascular Surgery 2004 40, 1190-1198DOI: (10.1016/j.jvs.2004.09.023) Copyright © 2004 The Society for Vascular Surgery Terms and Conditions

Fig 5 Gene expression of angiopoietins (Ang) and receptors (Tie). Reverse transcriptase–polymerase chain reaction analysis of Ang-1 and Ang-2, and Tie-1 and Tie-2 expression in carotid arteries implanted with radioactive coils (white bars) or nonradioactive coils (black bars). Results at 2, 6, or 15 days are expressed as ratio relative to expression found in normal carotid arteries (control arteries [CTL], gray bars). Decreased Ang-2 expression when carotid artery is occluded with radioactive coil occurred only on day 2 and did not reach statistical significance. Journal of Vascular Surgery 2004 40, 1190-1198DOI: (10.1016/j.jvs.2004.09.023) Copyright © 2004 The Society for Vascular Surgery Terms and Conditions