Microscopic Esophageal Mucosal Injury in Nonerosive Reflux Disease John Dent  Clinical Gastroenterology and Hepatology  Volume 5, Issue 1, Pages 4-16.e1 (January 2007) DOI: 10.1016/j.cgh.2006.08.006 Copyright © 2007 AGA Institute Terms and Conditions

Figure 1 Intercellular spaces in esophageal mucosa from a (A) healthy control subject and a (B) GERD patient without esophagitis observed by transmission electron microscopy. Reproduced with permission from Calabrese et al.11 Clinical Gastroenterology and Hepatology 2007 5, 4-16.e1DOI: (10.1016/j.cgh.2006.08.006) Copyright © 2007 AGA Institute Terms and Conditions

Figure 2 Intercellular spaces from esophageal mucosa in a (A) healthy control subject and a (B) GERD patient without macroscopic esophagitis observed by light microscopy. Reproduced with the kind permission of Roberto Fiocca, University of Genoa, Italy. Clinical Gastroenterology and Hepatology 2007 5, 4-16.e1DOI: (10.1016/j.cgh.2006.08.006) Copyright © 2007 AGA Institute Terms and Conditions

Figure 3 Biopsy specimen of esophageal mucosa from a (A) healthy control subject and a (B) GERD patient without esophagitis, showing papillary elongation and basal cell hyperplasia. Reproduced with the kind permission of Michael Vieth and Manfred Stolte, Institute of Pathology, Klinikum Bayreuth, Germany. Clinical Gastroenterology and Hepatology 2007 5, 4-16.e1DOI: (10.1016/j.cgh.2006.08.006) Copyright © 2007 AGA Institute Terms and Conditions