Platelet inhibition by adjunctive cilostazol suppresses the frequency of cerebral ischemic lesions after carotid artery stenting in patients with carotid.

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Platelet inhibition by adjunctive cilostazol suppresses the frequency of cerebral ischemic lesions after carotid artery stenting in patients with carotid artery stenosis Ichiro Nakagawa, MD, PhD, Takeshi Wada, MD, Hun Soo Park, MD, Fumihiko Nishimura, MD, PhD, Syuichi Yamada, MD, PhD, Hiroyuki Nakagawa, MD, PhD, Kimihiko Kichikawa, MD, PhD, Hiroyuki Nakase, MD, PhD Journal of Vascular Surgery Volume 59, Issue 3, Pages 761-767 (March 2014) DOI: 10.1016/j.jvs.2013.09.011 Copyright © 2014 Society for Vascular Surgery Terms and Conditions

Fig Pathways involved in platelet aggregation and possible mechanism involved in response to clopidogrel and cilostazol. Solid arrows indicate activation and dotted arrows indicate inhibition. AC, Adenylate cyclase; ADP, adenosine diphosphate; cAMP, cyclic adenosine monophosphate; CYP, cytochrome P; Gi, inhibitory G protein; PDE, phosphodiesterase; PKA, protein kinase A; VASP, vasodilator-stimulated phosphoprotein. Journal of Vascular Surgery 2014 59, 761-767DOI: (10.1016/j.jvs.2013.09.011) Copyright © 2014 Society for Vascular Surgery Terms and Conditions