Chapter 3 Opener.

Slides:



Advertisements
Similar presentations
How do drugs of abuse rewire the motivational circuitry?
Advertisements

Long-term Potentiation as a Physiological Phenomenon
LECTURE 9: INTEGRATION OF SYNAPTIC INPUTS (Ionotropic Receptors) REQUIRED READING: Kandel text, Chapter 12 At neuromuscular synapse, single axonal action.
Figure 8.1 Forms of short-term synaptic plasticity.
Part Fundamentals of Physiology Part II Food, Energy, and Temperature Part III Integrating systems Part IV Movement and Muscle Part V Oxygen, Carbon dioxide,
Neural Mechanisms of Memory Storage Molecular, synaptic, and cellular events store information in the nervous system. New learning and memory formation.
By Eamon Quick. The Rundown Long-Term Potentiation (LTP): activity-dependent increase in synaptic activity –Dependent upon NMDA receptor activation Favors.
Autophosphorylation at Thr 286 of the  Calcium- Calmodulin Kinase II in LTP and Learning Giese KP, Fedorov NB, Filipkowski RK, Silva AJ., Science Vol.
Synapses are everywhere neurons synapses Synapse change continuously –From msec –To hours (memory) Lack HH type model for the synapse.
Long term potentiation (LTP) of an excitatory synaptic inputs is input specific.
Using the Science of Learning (Neuroplasticity) To Inform Our Teaching Dorothy Kozlowski Ph.D. - Biology Christine Skolnik Ph.D. – WRD Sandra Virtue Ph.D.
J. Kauer, R. Malenka, and R. Nicoll
DAVID SANTUCCI QUANTITATIVE BIOLOGY BOOTCAMP 2009 A BRIEF HISTORY OF THE SYNAPSE.
Neuron schematic  G t = RT ln (c 2 /c 1 ) + zF  E axon myelin sheath dendrites nerve endings nt release nt receptors Cell body synapse.
Figure 8.1 The formation of a memory trace. Figure 8.2 Components of the classic Morris experiment.
Chapter 18. Synaptic Plasticity Copyright © 2014 Elsevier Inc. All rights reserved.
Molecular mechanisms of memory. How does the brain achieve Hebbian plasticity? How is the co-activity of presynaptic and postsynaptic cells registered.
Neural Plasticity: Long-term Potentiation Lesson 15.
Excitable cells and their biochemistry David Taylor
8 Memory Formation: Post-Translation Processes. The goal of this chapter and several that follow is to determine if some of the processes that have been.
From Mechanisms of Memory, second edition By J. David Sweatt, Ph.D. Chapter 9: Biochemical Mechanisms for Information Storage at the Cellular Level.
Lecture 7: Stochastic models of channels, synapses References: Dayan & Abbott, Sects 5.7, 5.8 Gerstner & Kistler, Sect 2.4 C Koch, Biophysics of Computation.
1 Synaptic Transmission. 2 Synaptic contacts Axodendritic – axon to dendrite Axodendritic – axon to dendrite Axosomatic – axon to soma Axosomatic – axon.
Glutamate Receptor Ion Channels: Structure, Regulation, and Function Department of Physiology, Shandong University School of Medicine ( Shu Yan Yu )
Chapter 44: Neurons and Nervous Systems CHAPTER 44 Neurons and Nervous Systems.
Receptors and transduction mechanisms - I The Neuron by Levitan & Kaczmarek – Chapter 11.
(1)Graded potentials on the post-synaptic membrane: depolarization and hyperpolarization; ligand-gated mechanisms (2) What happens at a synapse? A.  Transmitter.
LONG-TERM POTENTIATION (LTP) Introduction LTP as a candidate mechanism for the activity-dependent change in the strength of synaptic connections LTP is.
Trends in Biomedical Science Making Memory. The following slides are mostly derived from The Brain from Top to Bottom, an Interactive Website about the.
Doyle et al., Science 1998; 280: 69Jiang et al., Nature ; 523.
Neurotransmitters A. Criteria 1. must mimic presynaptic effects if administered exogenously 2. must be released during activity of presynaptic neuron 3.
Neural Mechanisms of Learning & Memory Lesson 24.
Fear conditioning… e.g., Electric shock associated with specific stimuli.
Fundamentals of Human Neuropsychology
Long Term Potentiation
Neurons and Nervous Systems
Hypothetical mechanism of ketamine’s antidepressant effects
Structure of a Neuron: At the dendrite the incoming
Chapter6 Ligand-gated Channels of Fast Chemical Synapses
Figure 1. Basal transmission in the dentate gyrus in vivo is not affected by drug injection. (A) Application of 61 μg of the selective mGliuR3 antagonist.
Neurotransmitter Receptors
Daniel Saal, Yan Dong, Antonello Bonci, Robert C Malenka  Neuron 
Chapter 16. Postsynaptic Potentials and Synaptic Integration
Synaptic transmission: Spillover in the spotlight
Schematic representation of brain targets common to the neurobiology and pharmacology of epilepsy and aggression. Schematic representation of brain targets.
Introduction to CNS pharmacology
Christian Lüscher, Robert C Malenka, Roger A Nicoll  Neuron 
NMDA Receptor-Dependent LTD Requires Transient Synaptic Incorporation of Ca2+- Permeable AMPARs Mediated by AKAP150-Anchored PKA and Calcineurin  Jennifer L.
Volume 68, Issue 4, Pages (November 2010)
Causes of Schizophrenia:
A Brief History of Long-Term Potentiation
Synapse.
PSA–NCAM Is Required for Activity-Induced Synaptic Plasticity
Myosin Learns to Recruit AMPA Receptors
Learning about Synaptic GluA3
Yu Tian Wang, David J. Linden  Neuron 
Volume 123, Issue 1, Pages (October 2005)
Dendritic Spine Geometry: Functional Implication and Regulation
Huibert D Mansvelder, Daniel S McGehee  Neuron 
Angelman Syndrome: Finding the Lost Arc
LTP Inhibits LTD in the Hippocampus via Regulation of GSK3β
Communication Between Neurons
Can Eph Receptors Stimulate the Mind?
The Back and Forth of Dendritic Plasticity
Small G Protein Signaling in Neuronal Plasticity and Memory Formation: The Specific Role of Ras Family Proteins  Xiaojing Ye, Thomas J. Carew  Neuron 
Biological Functions of Activity-Dependent Transcription Revealed
Volume 68, Issue 4, Pages (November 2010)
Dendritic Tau in Alzheimer’s Disease
Cell to cell communication in the nervous system
Homeostatic Systems and Drugs
Presentation transcript:

Chapter 3 Opener

Figure 3.1 A schematic representation of an excitatory synapse

Figure 3.1 A schematic representation of an excitatory synapse (Part 1)

Figure 3.1 A schematic representation of an excitatory synapse (Part 2)

Figure 3.2 The signaling cascade

Figure 3.3 Kinases are composed of an inhibitory and a catalytic domain

Figure 3.4 Ionotropic receptors

Figure 3.4 Ionotropic receptors (Part 1)

Figure 3.4 Ionotropic receptors (Part 2)

Figure 3.5 There are three types of glutamate receptors

Figure 3.6 The agonistic and antagonistic actions of drugs

In-Text Art, Ch. 3, p. 50 Graham Collingridge

Figure 3.7 APV, an NMDA receptor antagonist, prevents the induction of LTP but has no effect on its expression

Figure 3.8 The NMDA receptor

Figure 3.8 The NMDA receptor (Part 1)

Figure 3.8 The NMDA receptor (Part 2)

In-Text Art, Ch. 3, p. 53 Gary Lynch

Figure 3.9 AMPA receptors traffic into and out of dendritic spines

Figure 3.10 The number of theta-burst stimuli (TBS) determines the duration of LTP

Figure 3.11 A sequence of events leading to the induction of LTP

Figure 3.12 Changes in synaptic strength that support LTP