Pharmacodynamic properties of HMR 3004, a novel ketolide, on respiratory pathogens, enterococci and Bacteroides fragilis demonstrated by studies of time.

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Pharmacodynamic properties of HMR 3004, a novel ketolide, on respiratory pathogens, enterococci and Bacteroides fragilis demonstrated by studies of time kill kinetics and postantibiotic effect  F.J. Boswell, J.M. Andrews, R. Wise  Clinical Microbiology and Infection  Volume 4, Issue 4, Pages 186-191 (April 1998) DOI: 10.1111/j.1469-0691.1998.tb00667.x Copyright © 1998 European Society of Clinical Infectious Diseases Terms and Conditions

Figure 1 HMR 3004 time kill curves of (a) Staphylococcus aureus ATCC 29213, (b) E.faecalis T398, (c) B. fragilis B1, (d) Streptococcus pneumoniae P591, (e) Streptococcus pyogenes P199, and (f) M. catarrhalis R65. —, control; —, 2 × MIC; …, 10 × MIC. Clinical Microbiology and Infection 1998 4, 186-191DOI: (10.1111/j.1469-0691.1998.tb00667.x) Copyright © 1998 European Society of Clinical Infectious Diseases Terms and Conditions

Figure 2 HMR 3004 postantibiotic effect on (a) Staphylococcus aureus ATCC 29213, (b) E.faecalis T398, (c) B.fragilis B1.—, control; —, 1 × MIC; …. 4 × MIC; –, 10 × MIC. Clinical Microbiology and Infection 1998 4, 186-191DOI: (10.1111/j.1469-0691.1998.tb00667.x) Copyright © 1998 European Society of Clinical Infectious Diseases Terms and Conditions

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