Volume 24, Issue 3, Pages R109-R110 (February 2014) Wiring economy can account for cell body placement across species and brain areas  Marta Rivera-Alba, Hanchuan Peng, Gonzalo G. de Polavieja, Dmitri B. Chklovskii  Current Biology  Volume 24, Issue 3, Pages R109-R110 (February 2014) DOI: 10.1016/j.cub.2013.12.012 Copyright © 2014 Elsevier Ltd Terms and Conditions

Figure 1 The relative volume of cell bodies and stems determines the arrangement of cell bodies across species and brain areas. (A) Example of an embedded arrangement: mammalian cortical tissue with a subset of neurons labeled using Golgi stain [1]. (B) Example of a segregated arrangement in invertebrates: an electron micrograph of the cross-section of the ventral nerve cord (the view is toward anterior, dorsal is up) of the first instar Drosophila larva. A tracing of a typical interneuron is overlaid. Colors here and in (D–G): magenta, cell body; cyan, stem; blue, neurites; green, neuropile outline. Data and reconstruction courtesy of Casey Schneider-Mizell, Albert Cardona and Rick Fetter. (C) Example of a segregated arrangement in vertebrates: mammalian dentate gyrus with neurons stained using Brainbow [S1,S2]. Imaged by Tamily Weissman. (D) Non-economical embedded configuration. Here and in (E–G): green outline, economical neuropile; dashed red outline, non-economical neuropile. (E) Economical segregated configuration. (F) Economical embedded configuration. (G) Non-economical segregated configuration (H) Volume of the stem versus volume of the cell body for different species and brain areas. Colored arrows show wiring economy prediction. Green, embedded neuropiles; magenta, segregated neuropiles; dashed black line, Vcell body = Vstem. For the actual embedded neuropiles the volume of a projected stem has been computed; see Supplemental Information for full experimental procedures. Current Biology 2014 24, R109-R110DOI: (10.1016/j.cub.2013.12.012) Copyright © 2014 Elsevier Ltd Terms and Conditions