Effect of aprotinin on clinical outcomes in coronary artery bypass graft surgery: A systematic review and meta-analysis of randomized clinical trials

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Presentation transcript:

Effect of aprotinin on clinical outcomes in coronary artery bypass graft surgery: A systematic review and meta-analysis of randomized clinical trials Artyom Sedrakyan, MD, PhD, Tom Treasure, MD, FRCS, John A. Elefteriades, MD, FACS The Journal of Thoracic and Cardiovascular Surgery Volume 128, Issue 3, Pages 442-448 (September 2004) DOI: 10.1016/j.jtcvs.2004.03.041

Figure 1 Reported outcomes and blood transfusion requirements in the aprotinin and placebo groups. Data detailing numbers of events and patients randomized are cumulative for all trials; RRs were calculated according to methods described in Statistical Analysis section. The Journal of Thoracic and Cardiovascular Surgery 2004 128, 442-448DOI: (10.1016/j.jtcvs.2004.03.041)

Figure 2 Reported outcomes and blood transfusion requirements in the aprotinin and placebo groups stratified by aspirin users (upper panel) and nonusers (lower panel). Study participants were considered preoperative aspirin users if investigators did not exclude patients taking aspirin 7 days before surgery. Data detailing numbers of events and patients randomized are cumulative for all trials; RRs were calculated according to methods described in Statistical Analysis section.Cadmus, please print the online-only material and send to the author so that the author can proof it. This includes Appendix Figure 1 and Appendix Tables 1 and 2. The Journal of Thoracic and Cardiovascular Surgery 2004 128, 442-448DOI: (10.1016/j.jtcvs.2004.03.041)