Volume 90, Pages 8-12 (January 2019)

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Volume 90, Pages 8-12 (January 2019) Hypothesis: Presymptomatic treatment of Sturge-Weber Syndrome With Aspirin and Antiepileptic Drugs May Delay Seizure Onset Alyssa M. Day, BA, Adrienne M. Hammill, MD, PhD, Csaba Juhász, MD, PhD, Anna L. Pinto, MD, PhD, E. Steve Roach, MD, Charles E. McCulloch, PhD, Anne M. Comi, MD Karen L. Ball, BS, Brian J. Fisher, BBA, Jim I. Koenig, PhD, Michael T. Lawton, MD, Warren D. Lo, MD, Douglas A. Marchuk, PhD, Daniel K. Miles, MD, Marsha A. Moses, PhD, Angus A. Wilfong, MD Alyssa M. Day, BA, Adrienne M. Hammill, MD, PhD, Csaba Juhász, MD, PhD, Anna L. Pinto, MD, PhD, E. Steve Roach, MD, Charles E. McCulloch, PhD, Anne M. Comi, MD Karen L. Ball, BS, Brian J. Fisher, BBA, Jim I. Koenig, PhD, Michael T. Lawton, MD, Warren D. Lo, MD, Douglas A. Marchuk, PhD, Daniel K. Miles, MD, Marsha A. Moses, PhD, Angus A. Wilfong, MD Pediatric Neurology Volume 90, Pages 8-12 (January 2019) DOI: 10.1016/j.pediatrneurol.2018.04.009 Copyright © 2019 Terms and Conditions

FIGURE 1 Process of participant selection using our SWS Center research database. SWS: Sturge-Weber syndrome Pediatric Neurology 2019 90, 8-12DOI: (10.1016/j.pediatrneurol.2018.04.009) Copyright © 2019 Terms and Conditions

FIGURE 2 Medians of the neuroscores of presymptomatic treatment (aspirin only) versus postsymptomatic treatment. Graph of the medians and ranges of the neurological scores of those presymptomatically treated with aspirin only and postsymptomatically treated. *There were significant differences between the two groups (Wilcoxon-signed rank test). Pediatric Neurology 2019 90, 8-12DOI: (10.1016/j.pediatrneurol.2018.04.009) Copyright © 2019 Terms and Conditions

FIGURE 3 Medians of the neuroscores of presymptomatic treatment (aspirin and anti-epileptic) versus postsymptomatic treatment. Graph of the medians and ranges of the neurological scores of those presymptomatically treated with both aspirin and antiepileptic drugs versus those postsymptomatically treated. *The seizure subscore is significantly lower for those given presymptomatic treatment (Wilcoxon-signed rank test, P < 0.05). Pediatric Neurology 2019 90, 8-12DOI: (10.1016/j.pediatrneurol.2018.04.009) Copyright © 2019 Terms and Conditions