Type 2 Diabetes TCF7L2 Risk Genotypes Alter Birth Weight: A Study of 24,053 Individuals  Rachel M. Freathy, Michael N. Weedon, Amanda Bennett, Elina Hyppönen, Caroline L. Relton, Beatrice Knight, Beverley Shields, Kirstie S. Parnell, Christopher J. Groves, Susan M. Ring, Marcus E. Pembrey, Yoav Ben-Shlomo, David P. Strachan, Chris Power, Marjo-Riitta Jarvelin, Mark I. McCarthy, George Davey Smith, Andrew T. Hattersley, Timothy M. Frayling  The American Journal of Human Genetics  Volume 80, Issue 6, Pages 1150-1161 (June 2007) DOI: 10.1086/518517 Copyright © 2007 The American Society of Human Genetics Terms and Conditions

Figure 1 Meta-analysis of the association of birth weight (corrected for sex and gestation) with fetal rs7903146 genotype across six studies, arranged in order of increasing size. The effect size (in grams) and 95% CI per risk allele is presented. Combined per-allele difference=18 g (95% CI 7–29 g); P=.001; I2=21.0%. The American Journal of Human Genetics 2007 80, 1150-1161DOI: (10.1086/518517) Copyright © 2007 The American Society of Human Genetics Terms and Conditions

Figure 2 Meta-analysis of the association of birth weight (corrected for sex and gestation) with maternal rs7903146 genotype across three studies, arranged in order of increasing size. The effect size (in grams) and 95% CI per risk allele is presented. Combined per-allele difference=30 g (95% CI 15–45 g); P=2.8×10−5. I2=14.3%. The American Journal of Human Genetics 2007 80, 1150-1161DOI: (10.1086/518517) Copyright © 2007 The American Society of Human Genetics Terms and Conditions

Figure 3 Bar graph showing sex- and gestational age–corrected birth-weight Z score plotted against the number of maternal risk alleles for TCF7L2 rs7903146 and GCK rs1799884. Error bars show 95% CIs. The American Journal of Human Genetics 2007 80, 1150-1161DOI: (10.1086/518517) Copyright © 2007 The American Society of Human Genetics Terms and Conditions