Type 1 immunity drives metabolic disease but protects against NAFLD

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Date of download: 7/6/2016 Copyright © 2016 SPIE. All rights reserved. Representative magnitude images and PDFF maps of LFD and HFD mice at 4, 8, 12, and.

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Peter L. Lee, Yuefeng Tang, Huawei Li, David A. Guertin

Volume 19, Issue 1, Pages (January 2014)

Fig. 1 CSF1 is increased in blood of melanoma patients and correlates with disease progression. CSF1 is increased in blood of melanoma patients and correlates.

Fig. 4. Primary human metastatic melanomas contain CCL21-expressing LECs, and expression of VEGFC positively correlates with hallmarks of tumor inflammation.

Fig. 1. Generation of ERY974. Generation of ERY974. (A) Schematic illustration of ERY974 structure and the introduced mutations. The two Fab arms share.

The gene encoding TP53INP1 is expressed in pancreatic endocrine cells A, B(A, B) Immunocytofluorescent staining of TP53INP1 (red) and insulin (green) in.

Volume 21, Issue 5, Pages (May 2015)

Fig. 4. Intramuscular injection of AAV9-Cas9/sgRNA-51 corrects dystrophin expression. Intramuscular injection of AAV9-Cas9/sgRNA-51 corrects dystrophin.

Volume 16, Issue 10, Pages (September 2016)

Fig. 4. Bexarotene promotes PPARδ activation of target genes in mouse brain and muscle. Bexarotene promotes PPARδ activation of target genes in mouse brain.

Fig. 5. Correlation of tail and long bone growth velocities with Cxm serum concentrations in mice. Correlation of tail and long bone growth velocities.

Fig. 1. APP/PS1;C3 KO mice show improved cognitive flexibility (reversal) compared to APP/PS1 mice at 16 months of age. APP/PS1;C3 KO mice show improved.

Fig. 4. NASH-driven fibrosis is partly TGF-β–dependent.

Fig. 5 Maraba induces antitumor T cell immunity.

Fig. 3. Obese IFN-γ−/− mice develop accelerated NAFLD with fibrosis.

Fig. 6. Treatment with a DLK inhibitor is neuroprotective and reverses stress-induced gene expression changes. Treatment with a DLK inhibitor is neuroprotective.

Volume 22, Issue 1, Pages (July 2015)

Fig. 6 Bimodal treatment results in reduced tinnitus loudness and reduced TFI scores in human patients. Bimodal treatment results in reduced tinnitus loudness.

Fig. 1 pDCs infiltrate the skin of SSc patients and spontaneously secrete IFN-α and CXCL4. pDCs infiltrate the skin of SSc patients and spontaneously secrete.

Fig. 1. NASH and fibrosis develop late in mice fed an HFD.

Fig. 8. mRIPO elicits neutrophil influx followed by DC and T cell infiltration into tumors. mRIPO elicits neutrophil influx followed by DC and T cell infiltration.

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TFE3 prevents diet‐induced obesity and metabolic syndrome

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Fig. 8. Therapeutic effects of the transplantation of hiPSC-EPO–producing cells on renal anemia in adenine-treated mice. Therapeutic effects of the transplantation.

Fig. 5. Vascularization of human liver seed grafts.

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Fig. 2 In vitro assessment of hESC-RPE cell sheets.

Fig. 6. Safety assessment in cynomolgus monkey.

Fig. 5. MasSpec Pen analysis of an HGSC tissue sample with mixed histologic composition. MasSpec Pen analysis of an HGSC tissue sample with mixed histologic.

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Fig. 5. MMP-7 expression in human liver, EHBD, and gallbladder.

Fig. 5 Hypoxic tumors from obese mice associate with increased production of IL-6 by adipocytes and myeloid cells. Hypoxic tumors from obese mice associate.

Fig. 4. Expression of HGF in liver ECs cooperates with NOX4 inhibition to enhance engraftment of regenerative hepatocytes. Expression of HGF in liver ECs.

Fig. 4. BET inhibition sensitizes HR-proficient tumors to PARPi treatment in vivo. BET inhibition sensitizes HR-proficient tumors to PARPi treatment in.

Fig. 5. Accelerated NASH-driven fibrogenesis in obese IFN-γ−/− mice is characterized by severe eosinophilic inflammation during TGF-β blockade. Accelerated.

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Fig. 7 Improvement of clinical score and axon pathology by nasal IL-4 treatment during chronic EAE. Improvement of clinical score and axon pathology by.

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Fig. 1 Schematic of experimental design.

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Fig. 5 Treatment with an OX40 agonist antibody of 3-week-old HBVtgRag−/− mice or mice with chronic HBV disease results in an altered immune response to.

Fig. 6 Transmissibility of adiposity from humanized mice to germ-free recipients. Transmissibility of adiposity from humanized mice to germ-free recipients.

Fig. 2. Body weight and size analysis of A1/A2-KO mice

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Fig. 4 Effects of hematopoietic restoration of TLR9 on adipose tissue inflammation and insulin resistance. Effects of hematopoietic restoration of TLR9.

Fig. 3 Mmp-2−/− mice are protected from obesity and leptin resistance.

A B Figure S1, Effect of CH diet consumption for six weeks on mice hepatic morphology. Representative histologic microphotographs of H&E stained liver.

Fig. 1. GDF15 is up-regulated with obesity, and AAV-GDF15 improves metabolic parameters in DIO mice. GDF15 is up-regulated with obesity, and AAV-GDF15.

Fig. 1 Obesity-related adipocyte degeneration and cfDNA release.

Fig. 3. Effects of SFN in mice with diet-induced diabetes.

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Fig. 2. Type 1 immunity drives metabolic disease but protects against NAFLD. Type 1 immunity drives metabolic disease but protects against NAFLD. WT (circles), IL-4−/− (squares), and IL-10/IL-4−/− (triangles) mice were maintained on a normal diet (filled symbols) or HFD (open symbols) for 15 weeks. Obesity was measured by magnetic resonance imaging (MRI) body composition (A) (n = 4 to 6), and serum leptin levels were assessed by enzyme-linked immunosorbent assay (n = 3 to 7) (B). NAFLD progression was assessed by liver weight and indices (n = 8 to 15) (C), hepatic triglyceride measurement (n = 8 to 11), serum aminotransferase levels (n = 4 to 17) (D), and Giemsa-stained liver sections (E). KO, knockout. Adipose inflammation was assessed through histological analysis of H&E-stained adipose sections (scale bars, 150 μm) (F), adipose tissue expression of tnf and ccl2 (n = 3 to 11) (G), and flow cytometry analysis of adipose eosinophils (n = 4 to 11) (H). All data points represent a single mouse, and representative or pooled data from two or more independent experiments are shown (two-tailed t tests, n = 2 to 10; *P < 0.05, **P < 0.01, ***P < 0.005, ****P < 0.0001). Kevin M. Hart et al., Sci Transl Med 2017;9:eaal3694 Published by AAAS