Improvements achieved in an oocyte donation program over a 10-year period: sequential increase in implantation and pregnancy rates and decrease in high-order.

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Presentation transcript:

Improvements achieved in an oocyte donation program over a 10-year period: sequential increase in implantation and pregnancy rates and decrease in high-order multiple pregnancies Erdal Budak, M.D., Nicolas Garrido, Ph.D., Sergio Reis Soares, M.D., Marco Antonio Barreto Melo, M.D., Marcos Meseguer, Ph.D., Antonio Pellicer, M.D., José Remohí, M.D. Fertility and Sterility Volume 88, Issue 2, Pages 342-349 (August 2007) DOI: 10.1016/j.fertnstert.2006.11.118 Copyright © 2007 American Society for Reproductive Medicine Terms and Conditions

FIGURE 1 Indications for oocyte donation (cycles with embryo transfer = 7,186). POF = premature ovarian failure, RIF = recurrent IVF failure, RM = recurrent miscarriage. Budak. Evolution of a large oocyte donation program over a 10-year period. Fertil Steril 2007. Fertility and Sterility 2007 88, 342-349DOI: (10.1016/j.fertnstert.2006.11.118) Copyright © 2007 American Society for Reproductive Medicine Terms and Conditions

FIGURE 2 Trends in number of embryos replaced in oocyte donation cycles between 1995 and 2005. Significantly fewer number of embryos were replaced with each successive period. ET = embryo transfer. Budak. Evolution of a large oocyte donation program over a 10-year period. Fertil Steril 2007. Fertility and Sterility 2007 88, 342-349DOI: (10.1016/j.fertnstert.2006.11.118) Copyright © 2007 American Society for Reproductive Medicine Terms and Conditions

FIGURE 3 Trends in different cycle outcome parameters in oocyte donation cycles between 1995 and 2005. Budak. Evolution of a large oocyte donation program over a 10-year period. Fertil Steril 2007. Fertility and Sterility 2007 88, 342-349DOI: (10.1016/j.fertnstert.2006.11.118) Copyright © 2007 American Society for Reproductive Medicine Terms and Conditions

FIGURE 4 Cumulative PRs rates in relation to different age groups: similar cumulative PR curves were observed for different age groups (P<.05). Budak. Evolution of a large oocyte donation program over a 10-year period. Fertil Steril 2007. Fertility and Sterility 2007 88, 342-349DOI: (10.1016/j.fertnstert.2006.11.118) Copyright © 2007 American Society for Reproductive Medicine Terms and Conditions

FIGURE 5 Cumulative PRs in relation to indication for oocyte donation. Budak. Evolution of a large oocyte donation program over a 10-year period. Fertil Steril 2007. Fertility and Sterility 2007 88, 342-349DOI: (10.1016/j.fertnstert.2006.11.118) Copyright © 2007 American Society for Reproductive Medicine Terms and Conditions

FIGURE 6 Cumulative PRs in relation to sperm origin. MF = male factor. Budak. Evolution of a large oocyte donation program over a 10-year period. Fertil Steril 2007. Fertility and Sterility 2007 88, 342-349DOI: (10.1016/j.fertnstert.2006.11.118) Copyright © 2007 American Society for Reproductive Medicine Terms and Conditions