Covering the Cover Gastroenterology Anson W. Lowe, Richard H. Moseley  Gastroenterology  Volume 147, Issue 4, Pages 721-724 (October 2014) DOI: 10.1053/j.gastro.2014.08.024 Copyright © 2014 AGA Institute Terms and Conditions

Figure 1 Viability of 3 different bacteria in macrophages after chronic NOD2 stimulation with muramyl dipeptide (MDP). Increased viable bacteria in the presence of MDP were observed if metallothionein expression was reduced with metal-regulatory transcription factor-1 small interfering RNA. Gastroenterology 2014 147, 721-724DOI: (10.1053/j.gastro.2014.08.024) Copyright © 2014 AGA Institute Terms and Conditions

Figure 2 Higher production of cytokines by HCV-specific CD4 T cells from SR/SR patients as compared with SR/CI patients during reinfection. PBMCs were stimulated with overlapping peptide pools representing HCV (NS3 and NS5B) and pools showing the highest response in the IFN gamma ELISPOT, then ICS was performed to measure the production of IFNγ, interleukin 2 (IL2), and TNFα. Representative results from 2 SR/SR patients (A, B) and 2 SR/CI patients (C, D), gated on CD4+ CD3+ viable T lymphocytes. Peptide pools are indicated between brackets and represent the following regions: NS3-1 (NS3 aa: 1016–1341), NS5B-1 (NS5B; aa: 2416–2720), and NS5B-2 (NS5B; aa: 2710–3014). For polyfunctionality, orange represents triple functional cells, green represents double functional, and yellow represents monofunctional cells of any combination. Gastroenterology 2014 147, 721-724DOI: (10.1053/j.gastro.2014.08.024) Copyright © 2014 AGA Institute Terms and Conditions

Figure 3 Growth of pancreatic cancer cell line xenografts in mice. (A) KRAS-dependent cells. (B) KRAS-independent cells. Dotted line, short hairpin HNRNPA2B1 RNA knockdown; solid line, vector control. Gastroenterology 2014 147, 721-724DOI: (10.1053/j.gastro.2014.08.024) Copyright © 2014 AGA Institute Terms and Conditions