Volume 66, Issue 2, Pages 412-423 (February 2017) Personalized treatment of patients with very early hepatocellular carcinoma  Alessandro Vitale, Markus Peck-Radosavljevic, Edoardo G. Giannini, Eric Vibert, Wolfgang Sieghart, Sven Van Poucke, Timothy M. Pawlik  Journal of Hepatology  Volume 66, Issue 2, Pages 412-423 (February 2017) DOI: 10.1016/j.jhep.2016.09.012 Copyright © 2016 European Association for the Study of the Liver Terms and Conditions

Fig. 1 Evidence based treatment algorithm of very early HCC. Adapted from the BCLC staging classification and treatment algorithm [6]. PS, performance status. Journal of Hepatology 2017 66, 412-423DOI: (10.1016/j.jhep.2016.09.012) Copyright © 2016 European Association for the Study of the Liver Terms and Conditions

Fig. 2 Impact of tumor location on extension of LR. (A) HCC with a deep location in the right liver requiring major laparotomic resection. (B) HCC located on the surface of anterior segments requiring mini invasive surgery. Journal of Hepatology 2017 66, 412-423DOI: (10.1016/j.jhep.2016.09.012) Copyright © 2016 European Association for the Study of the Liver Terms and Conditions

Fig. 3 Personalized treatment of very early HCC. Adapted from recent evidences calculating the impact of extension of liver resection (LR), portal hypertension, MELD score, [64] and laparoscopic approach [66,81] on the risk of postoperative liver decompensation (LD). This algorithm assigns LR only to very early HCC patients with a predicted low risk of postoperative LD. PS, performance status; MELD, model for end-stage liver disease. Journal of Hepatology 2017 66, 412-423DOI: (10.1016/j.jhep.2016.09.012) Copyright © 2016 European Association for the Study of the Liver Terms and Conditions