Antithrombotic Therapy in PAD

Peripheral Artery Disease (PAD) Prevalence and Clinical Awareness

Risk Factors for PAD

Identifying Patients With PAD Importance of History and Performing Ankle-Brachial Index

Lower Extremity Amputation Geographic Variation in the United States

Comprehensive Approach to Management Needed

COMPASS Active and Nonactive Clinical Conditions at Baseline

Goals of Therapy

Patients With PAD in Denmark

US Analysis Also Found Underuse of Guideline-Recommended Therapies for PAD

Antiplatelet Therapy for PAD AHA/ACC Guidelines Class I, IIa

Anticoagulation in PAD WAVE

COMPASS 27,395 Subjects, 602 Sites, 33 Countries

COMPASS Population

COMPASS Primary Outcome CV Death, Stroke, MI

COMPASS Components of Primary Outcome

COMPASS Cumulative Incidence Risk of MACE

COMPASS: Composite Outcomes for PAD CV Death, Stroke, MI, MALE (Including Major Amputation)

COMPASS PAD Subgroup Major Adverse Limb Events (MALE) and Major Amputation

COMPASS Major Bleeding (PAD Subgroup)

Rivaroxaban FDA Approval

COMPASS Independent Predictors of MALE

Patient Considerations: Those at Highest Risk

VOYAGER PAD Ongoing

Recent Pathology Research Examines Below and Above Knee Amputations

Summary

Abbreviations

Abbreviations (cont)