Efficient Healing Takes Some Nerve: Electrical Stimulation Enhances Innervation in Cutaneous Human Wounds  Elaine Emmerson  Journal of Investigative Dermatology  Volume 137, Issue 3, Pages 543-545 (March 2017) DOI: 10.1016/j.jid.2016.10.018 Copyright © 2016 The Author Terms and Conditions

Figure 1 Schematic depicting innervation of the skin. Sensory nerves (in blue) extend into both the dermis and epidermis and control mechanosensation, thermosensation, and nociception. Sympathetic nerves of the autonomic nervous system (in green) extend only into the dermis, where they innervate skin appendages, including sebaceous glands (in red), hair follicles, and arrector pili muscles. Journal of Investigative Dermatology 2017 137, 543-545DOI: (10.1016/j.jid.2016.10.018) Copyright © 2016 The Author Terms and Conditions

Figure 2 Diagrammatical representation of the different phases of wound healing influenced by the release of neurotransmitters and neuropeptides by cutaneous nerves. Neurotransmitters and neuropeptides influence keratinocyte proliferation and re-epithelialization, cytokine release, granulation tissue formation, angiogenesis, wound contraction, collagen deposition and remodeling and nerve regeneration. Journal of Investigative Dermatology 2017 137, 543-545DOI: (10.1016/j.jid.2016.10.018) Copyright © 2016 The Author Terms and Conditions