Do Statins Have a Role in the Promotion of Postoperative Wound Healing in Cardiac Surgical Patients? Gerard J. Fitzmaurice, MRCSI, MS, Billy McWilliams,

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Do Statins Have a Role in the Promotion of Postoperative Wound Healing in Cardiac Surgical Patients? Gerard J. Fitzmaurice, MRCSI, MS, Billy McWilliams, MS, Lars Nölke, FRCS (CTh), J. Mark Redmond, MD, FRCS (CTh), Jonathan G. McGuinness, PhD, FRCS (CTh), Mark E. O'Donnell, MD, FRCS The Annals of Thoracic Surgery Volume 98, Issue 2, Pages 756-764 (August 2014) DOI: 10.1016/j.athoracsur.2014.02.089 Copyright © 2014 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 An overview of the phases of normal wound healing, including the main cell types involved. (Reprinted from Lancet, Vol. 366, Falanga V, Wound healing and its impairment in the diabetic foot, pages 1736–43. Copyright 2005, with permission from Elsevier [11].) The Annals of Thoracic Surgery 2014 98, 756-764DOI: (10.1016/j.athoracsur.2014.02.089) Copyright © 2014 The Society of Thoracic Surgeons Terms and Conditions

Fig 2 An overview of the cells involved in wound healing and the products they produce. (bFGF = basic fibroplastic growth factor; EGF = epidermal growth factor; IFN = interferon; IGF = insulin-like growth factor; KGF = keratinocyte growth factor; IL = interleukin; PDGF = platelet-derived growth factor; TGF = transforming growth factor; TNF = tumor necrosis factor; VEGF = vascular endothelial growth factor.) (Reprinted from Surg Clin North Am, Vol. 89(3), Teller P, White TK, The physiology of wound healing: injury through maturation, pages 599–610. Copyright 2009, with permission from Elsevier [37].) The Annals of Thoracic Surgery 2014 98, 756-764DOI: (10.1016/j.athoracsur.2014.02.089) Copyright © 2014 The Society of Thoracic Surgeons Terms and Conditions

Fig 3 An overview of the literature search strategy with the identification of studies eligible for inclusion in the review. The Annals of Thoracic Surgery 2014 98, 756-764DOI: (10.1016/j.athoracsur.2014.02.089) Copyright © 2014 The Society of Thoracic Surgeons Terms and Conditions