Exploiting Old Pathogens to Create New Therapeutics Tiffany Bouchery, Nicola L. Harris  Cell Host & Microbe  Volume 20, Issue 6, Pages 705-707 (December 2016) DOI: 10.1016/j.chom.2016.11.007 Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 1 Modulation of Allergic Airway Inflammation by the Parasitic Protein AIP-2 Intestinal-dwelling hookworms secrete an array of proteins, including AIP-2, which is taken up by migratory CD103+ dendritic cells (DCs). CD103+ DCs then migrate to the draining mesenteric lymph nodes where they promote the activation and expansion of regulatory T cells over allergy-promoting effector T cells. This process can also be mimicked by peritoneal inoculation of total parasite secreted products or recombinant AIP-2 into mice. The presence of an increased regulatory T cell pool in turn suppresses the development of allergic immune responses in the lung. Cell Host & Microbe 2016 20, 705-707DOI: (10.1016/j.chom.2016.11.007) Copyright © 2016 Elsevier Inc. Terms and Conditions