Receiver operating curves (ROC) of the Framingham and QRISK2 risk factor models for predicting 10-year risk of cardiovascular disease with and without the inclusion of the AST/ALT ratio. Receiver operating curves (ROC) of the Framingham and QRISK2 risk factor models for predicting 10-year risk of cardiovascular disease with and without the inclusion of the AST/ALT ratio. ALT, alanine transaminase; AST, aspartate transaminase. Stephen F Weng et al. Open Heart 2015;2:e000272 ©2015 by British Cardiovascular Society