Chad M. Trent, Martin J. Blaser Cell Metabolism

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Microbially Produced Acetate: A “Missing Link” in Understanding Obesity? Chad M. Trent, Martin J. Blaser Cell Metabolism Volume 24, Issue 1, Pages 9-10 (July 2016) DOI: 10.1016/j.cmet.2016.06.023 Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 1 Models of Microbial Perturbations Enhancing Obesity High-fat diet feeding alters the gut microbiome, increasing both colonic and circulating levels of acetate, and similar increases in acetate after early life antibiotic perturbation of the microbiome also had been observed (Cho et al., 2012). Perry et al. (2016) have demonstrated that increased acetate results in parasympathetic activation, resulting in altered hormone secretion in the gastrointestinal tract (gastrin, ghrelin) and pancreas (insulin) that promote food intake and energy retention. Cell Metabolism 2016 24, 9-10DOI: (10.1016/j.cmet.2016.06.023) Copyright © 2016 Elsevier Inc. Terms and Conditions