Clavulanic acid can be the component in amoxicillin-clavulanic acid responsible for immediate hypersensitivity reactions Maria José Torres, MD, PhD,

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Presentation transcript:

Clavulanic acid can be the component in amoxicillin-clavulanic acid responsible for immediate hypersensitivity reactions Maria José Torres, MD, PhD, Adriana Ariza, PhD, Cristobalina Mayorga, PhD, Inmaculada Doña, MD, PhD, Natalia Blanca-Lopez, MD, PhD, Carmen Rondon, MD, PhD, Miguel Blanca, MD, PhD Journal of Allergy and Clinical Immunology Volume 125, Issue 2, Pages 502-505.e2 (February 2010) DOI: 10.1016/j.jaci.2009.11.032 Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Skin test results using amoxicillin (20 mg/mL), amoxicillin-clavulanic acid (20/4 mg/mL), and clavulanic acid (20 mg/mL) in patient 55C. On the left are shown prick results (all negative) and on the right intradermal results (only positive to clavulanic acid). Journal of Allergy and Clinical Immunology 2010 125, 502-505.e2DOI: (10.1016/j.jaci.2009.11.032) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Mean and SD of SI from BAT in positive cases in the 3 groups, with benzylpenicillin (BP), amoxicillin (AX), AX-CLV, and CLV at different concentrations (mg/mL). The AX-CLV concentration expresses the AX concentration in the combination. Journal of Allergy and Clinical Immunology 2010 125, 502-505.e2DOI: (10.1016/j.jaci.2009.11.032) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 A, Wortmannin inhibitory effect in basophil activation under different conditions: positive controls (fMLP and anti-IgE), benzylpenicillin (BP), amoxicillin (AX), AX-CLV, and CLV at different concentrations (mg/mL). These data show the mean SI from 4 patients of group C. B, BAT results at different CLV concentrations (1.25, 0.5, 0.25, and 0.05 mg/mL) during a follow-up period of 12 months. These figures represent individual data from 4 patients of group C. Journal of Allergy and Clinical Immunology 2010 125, 502-505.e2DOI: (10.1016/j.jaci.2009.11.032) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Dose -response curve for positive patients (N = 8) and controls (N = 8), responders to AX-CLV (A) or CLV (B). Results are expressed as the SIs (means ± SEMs). Journal of Allergy and Clinical Immunology 2010 125, 502-505.e2DOI: (10.1016/j.jaci.2009.11.032) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions