Volume 119, Issue 4, Pages 1096-1103 (October 2000) Circulating soluble vascular adhesion protein 1 accounts for the increased serum monoamine oxidase activity in chronic liver disease  Riikka Kurkijärvi, Gennady G. Yegutkin, Bridget K. Gunson, Sirpa Jalkanen, Marko Salmi, David H. Adams  Gastroenterology  Volume 119, Issue 4, Pages 1096-1103 (October 2000) DOI: 10.1053/gast.2000.18163 Copyright © 2000 American Gastroenterological Association Terms and Conditions

Fig. 1 SVAP-1 level is increased in chronic inflammatory liver disease. (A) Box and whisker plots for patients with liver disease. The significance levels for Wilcoxon rank sum test compared with controls are as follows: alcoholic cirrhosis (n = 35), P < 0.001; alcoholic hepatitis (n = 12), P < 0.01; hepatic vascular disease (n = 5), P < 0.01; cryptogenic cirrhosis (n = 9), P < 0.005; PBC (n = 21), P < 0.001; PSC (n = 13), NS; treated autoimmune hepatitis (AICAH; n = 5), NS; chronic viral hepatitis (n = 6), P < 0.05; fulminant hepatitis caused by paracetamol poisoning (n = 6), NS; long-term stable posttransplant patients (Post-Tx; n = 15), NS. The bold line represents the median value, the box encompasses the interquartile range, and the whiskers show the 5 and 95 centiles. The range of results in healthy controls is shown by the shaded area. (B) Serial samples in 5 patients with fulminant liver failure. NANB, patients with fulminant seronegative hepatitis; POD, patients with massive hepatic necrosis caused by paracetamol poisoning. The day after admission to our unit is shown on the x-axis. The 2 patients with NANB required emergency liver transplantation; those with paracetamol poisoning recovered. (C) Values for patients with liver cancer are shown in the same format for hepatocellular carcinoma (n = 14; P < 0.05 vs. controls), cholangiocarcinoma (n = 5; NS), and hepatic metastases from colorectal cancer (n = 12; NS). Gastroenterology 2000 119, 1096-1103DOI: (10.1053/gast.2000.18163) Copyright © 2000 American Gastroenterological Association Terms and Conditions

Fig. 2 Levels of sVAP-1 in paired peripheral venous blood, hepatic venous blood, and, for 5 patients, in portal blood. No significant differences were observed in hepatic vs. peripheral blood levels, but the levels in portal vein blood were significantly less than those in hepatic vein (2P < 0.043, Wilcoxon signed-rank sum test for pairs). Gastroenterology 2000 119, 1096-1103DOI: (10.1053/gast.2000.18163) Copyright © 2000 American Gastroenterological Association Terms and Conditions

Fig. 3 Levels of circulating sVAP-1 correlate closely with serum SSAO activity in normal subjects and patients with liver disease. sVAP-1 levels (ng/mL) and SSAO activity (nmol · mL−1 · h−1) for healthy controls, patients with liver disease (LD), and patients with hepatic necrosis caused by paracetamol poisoning (POD). Values are means ± SE. There is a highly significant correlation between SSAO activity and sVAP-1 (r = 0.895, Spearman rank correlation). Gastroenterology 2000 119, 1096-1103DOI: (10.1053/gast.2000.18163) Copyright © 2000 American Gastroenterological Association Terms and Conditions