Specific isoforms of leucine-rich α2-glycoprotein detected in the proliferative endometrium of women undergoing assisted reproduction are associated with.

Slides:

Advertisements

Similar presentations

Specificity and predictive value of circulating testosterone assessed by tandem mass spectrometry for the diagnosis of polycystic ovary syndrome by the.

Advertisements

Clinically significant and sustained weight loss is achievable in obese women with polycystic ovary syndrome followed in a regular medical practice Lysanne.

Gaps in knowledge among physicians regarding diagnostic criteria and management of polycystic ovary syndrome Anuja Dokras, M.D., Ph.D., Shailly Saini,

Age at menarche: a predictor of diminished ovarian function?

Local injury to the endometrium in controlled ovarian hyperstimulation cycles improves implantation rates Liang Zhou, M.D., Rong Li, M.D., Ph.D., Rong.

Fertility and Sterility Volume 97, Issue 3, Pages (March 2012)

Infertility evaluation and treatment among women in the United States

Risk of obstructive sleep apnea in obese and nonobese women with polycystic ovary syndrome and healthy reproductively normal women Babak Mokhlesi, M.D.,

No difference in cycle pregnancy rate and in cumulative live-birth rate between women with surgically treated minimal to mild endometriosis and women.

Bjørn Bay, M. D. , Erik Lykke Mortensen, M. Sc

Kalliopi Kotsa, M. D. , Ph. D. , Maria P. Yavropoulou, M. D

Michael M. Alper, M.D. Fertility and Sterility

Sperm DNA damage measured by the alkaline Comet assay as an independent predictor of male infertility and in vitro fertilization success Luke Simon,

Low-density lipoprotein receptor–related protein-5 C/T polymorphism in exon 18 is associated with C peptide and proinsulin levels in control women and.

Michal Youngster, M. D. , Valerie L. Ward, M. D. , M. P. H. , Emily A

Dennis J. Hand, Ph. D. , Vanessa L. Short, Ph. D. , M. P. H. , Diane J

Gaps in knowledge among physicians regarding diagnostic criteria and management of polycystic ovary syndrome Anuja Dokras, M.D., Ph.D., Shailly Saini,

Hepatitis and reproduction

Marcos Meseguer, Ph. D. , Rebeca Santiso, Ph. D. , Nicolás Garrido, Ph

Distribution of male infertility specialists in relation to the male population and assisted reproductive technology centers in the United States Ajay.

Robot-assisted laparoscopy for infertility treatment: current views

Proteomic analysis of seminal plasma from infertile patients with oligoasthenoteratozoospermia due to oxidative stress and comparison with fertile volunteers

Early loss rates of entire pregnancies after assisted reproduction are lower in twin than in singleton pregnancies Alexandra Matias, M.D., Giovanni B.

Insulin resistance in oligomenorrheic infertile women with non-polycystic ovary syndrome Shirei Ohgi, M.D., Koji Nakagawa, M.D., Ph.D., Rieko Kojima,

Risk of depression and other mental health disorders in women with polycystic ovary syndrome: a longitudinal study Angela Kerchner, B.A., Whitney Lester,

Medical treatment of ectopic pregnancy: a committee opinion

Expression of growth differentiation factor-9 and bone morphogenetic protein-15 in oocytes and cumulus granulosa cells of patients with polycystic ovary.

Comparative proteomic analysis of human adenomyosis using two-dimensional gel electrophoresis and mass spectrometry Haiyuan Liu, M.D., Jinghe Lang, M.D.,

Low fertility awareness in United States reproductive-aged women and medical trainees: creation and validation of the Fertility & Infertility Treatment.

Letrozole versus combined metformin and clomiphene citrate for ovulation induction in clomiphene-resistant women with polycystic ovary syndrome: a randomized.

Clinical course of depression symptoms and predictors of enduring depression risk in women with polycystic ovary syndrome: Results of a longitudinal study

Specificity and predictive value of circulating testosterone assessed by tandem mass spectrometry for the diagnosis of polycystic ovary syndrome by the.

Steroid hormone levels in pregnancy and 1 year postpartum using isotope dilution tandem mass spectrometry Offie P. Soldin, Ph.D., Tiedong Guo, M.Sc.,

Influence of acupuncture stimulation on pregnancy rates for women undergoing embryo transfer Caroline Smith, Ph.D., Meaghan Coyle, B.Hlth.Sc. (Acup.),

Hyperglycemia Stimulates Activation of Nuclear Factor κB (NFκB) in Mononuclear Cells (MNC) of Women With Polycystic Ovary Syndrome (PCOS) F. Gonzalez,

Management of tubal ectopic pregnancy: methotrexate and salpingostomy are preferred to preserve fertility Stephanie Beall, M.D., Ph.D., Alan H. DeCherney,

Jieqiang Lv, M. D. , Xueqiong Zhu, M. D. , Ph. D

Ovulation induction in women with polycystic ovary syndrome

Akanksha Mehta, M.D., Darius A. Paduch, M.D., Ph.D.

Evaluation of diagnostic testis biopsy and the repetition of testicular sperm extraction surgeries in infertility patients Alayman Hussein, M.B.B.C.H.,

Simone Ferrero, M. D. , David John Gillott, Ph. D

Birth outcomes after spontaneous or assisted conception among infertile Australian women aged 28 to 36 years: a prospective, population-based study Danielle.

Increased secretion of amylin in women with polycystic ovary syndrome

Follicular-fluid neurotrophin levels in women undergoing assisted reproductive technology for different etiologies of infertility Erkan Buyuk, M.D.,

“Information-rich” reproductive outcomes in carriers of a structural chromosome rearrangement ascertained on the basis of recurrent pregnancy loss Michelle.

One last chance for pregnancy: a review of 2,705 in vitro fertilization cycles initiated in women age 40 years and above Sigal Klipstein, M.D., Meredith.

Fleur R. Cattrall, M. B. B. S. , Beverley J. Vollenhoven, M. B. B. S

Metformin treatment before and during in vitro fertilization or intracytoplasmic sperm injection in women with polycystic ovary syndrome: summary of a.

Antoni J. Duleba, M.D., Ibrahim M. Ahmed, M.D. Fertility and Sterility

In vitro fertilization and breast cancer: is there cause for concern?

Metformin reduces serum müllerian-inhibiting substance levels in women with polycystic ovary syndrome after protracted treatment Richard Fleming, Ph.D.,

Simvastatin improves biochemical parameters in women with polycystic ovary syndrome: results of a prospective, randomized trial Antoni J. Duleba, M.D.,

Cameron Gilbert, M. Sc. , Maria Valois, M. D. , FRCPC, Ph. D

Pregnancy outcome in infertile patients with polycystic ovary syndrome who were treated with metformin Samuel S. Thatcher, M.D., Ph.D., Elizabeth M.

Stephanie A. Beall, M.D., Ph.D., Alan DeCherney, M.D.

Evaluation of Sperm Proteins in Infertile Men: A Proteomic Approach

Antral follicle counts are strongly associated with live-birth rates after assisted reproduction, with superior treatment outcome in women with polycystic.

Paolo Moghetti, M.D. Fertility and Sterility

Sedigheh Borna, M.D., Azita Nasery, M.D. Fertility and Sterility

Impact of subclinical hypothyroidism in women with recurrent early pregnancy loss Lia A. Bernardi, M.D., Ronald N. Cohen, M.D., Mary D. Stephenson, M.D.,

Comparison of clomiphene citrate, metformin, or the combination of both for first-line ovulation induction and achievement of pregnancy in 154 women with.

Current evaluation of amenorrhea

David H. Barad, M.D., M.S., Norbert Gleicher, M.D.

Glycolytic enzyme expression in human granulosa cells

Adiponectin levels reflect the different phenotypes of polycystic ovary syndrome: study in normal weight, normoinsulinemic patients Artemis Karkanaki,

Endometrial gene expression in the window of implantation is altered in obese women especially in association with polycystic ovary syndrome José Bellver,

Diabetes mellitus and insulin resistance in mothers, fathers, sisters, and brothers of women with polycystic ovary syndrome: a systematic review and meta-analysis

Is there a role for diet in ameliorating the reproductive sequelae associated with chronic low-grade inflammation in polycystic ovary syndrome and obesity?

Tamer M. Said, M. D. , Geetha Ranga, M. D. , Ashok Agarwal, Ph. D. , H

Rudimentary uterine horn pregnancy: a mystery diagnosis

Presentation transcript:

Specific isoforms of leucine-rich α2-glycoprotein detected in the proliferative endometrium of women undergoing assisted reproduction are associated with spontaneous pregnancy David J. Gillott, Ph.D., Hazem M. Al-Rumaih, M.D., Kit-Yi Leung, Ph.D., Abdallah Eldib, M.Sc., J. Gedis Grudzinskas, M.D. Fertility and Sterility Volume 90, Issue 3, Pages 761-768 (September 2008) DOI: 10.1016/j.fertnstert.2007.01.094 Copyright © 2008 American Society for Reproductive Medicine Terms and Conditions

Figure 1 Two-dimensional gel of uterine flushing showing the location of the train of leucine-rich α2-glycoprotein isoforms. Protein spots were identified by excision and in-gel trypsin digestion followed by high-performance liquid chromatography and tandem mass spectrometry. Identified amino acid sequences were used to search the protein sequence database maintained by the Swiss Institute of Bioinformatics (ExPASy, http://us.expasy.org). Fertility and Sterility 2008 90, 761-768DOI: (10.1016/j.fertnstert.2007.01.094) Copyright © 2008 American Society for Reproductive Medicine Terms and Conditions

Figure 2 Graphical representation of normalized mean spot volumes (y-axis) in pregnant and nonpregnant women (± standard error). (A) Analyzed by diagnostic group and according to spontaneous pregnancy, treatment-independent pregnancy, and nonpregnant. (B) Detail of two-dimensional gel showing position of relevant leucine-rich α2-glycoprotein isoforms. Fertility and Sterility 2008 90, 761-768DOI: (10.1016/j.fertnstert.2007.01.094) Copyright © 2008 American Society for Reproductive Medicine Terms and Conditions

Figure 3 Graphic representation of expression of (A) LRGiii and (B) LRGiv (bottom) for the spontaneous (spon), treatment-related pregnancies (treat), and nonpregnant groups for the diagnoses of male factor infertility, tubal disease, polycystic ovary syndrome, and unexplained infertility. The y-axis represents normalized volume. Fertility and Sterility 2008 90, 761-768DOI: (10.1016/j.fertnstert.2007.01.094) Copyright © 2008 American Society for Reproductive Medicine Terms and Conditions

Figure 4 Example of an ms/ms spectrum, in this case for the peptide ENQLEVLEVSWLHGLK (amino acid 149–164). The x-axis represents mass/charge (m/z). The spikes labeled y3–y13 represent the detection of variously sized peptide fragments. The individual amino acids are superimposed over the detected fragments showing the amino acid sequence of the fragmented peptide. Fertility and Sterility 2008 90, 761-768DOI: (10.1016/j.fertnstert.2007.01.094) Copyright © 2008 American Society for Reproductive Medicine Terms and Conditions