Immunology and the Lynch Syndrome

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Presentation transcript:

Immunology and the Lynch Syndrome Henry T. Lynch, Kristen M. Drescher, Albert de la Chapelle Gastroenterology Volume 134, Issue 4, Pages 1246-1249 (April 2008) DOI: 10.1053/j.gastro.2008.02.008 Copyright © 2008 AGA Institute Terms and Conditions

Figure 1 Generation of anti-tumor responses in MSI-H cancer. Mutations in MMR genes induce the expression of novel frameshift peptides by the tumor. Because the patient has not been tolerized to these peptides, a potent immune response to the peptides develops. This resultant immune response helps control tumor growth and spread. Gastroenterology 2008 134, 1246-1249DOI: (10.1053/j.gastro.2008.02.008) Copyright © 2008 AGA Institute Terms and Conditions