Stuart M. Levitz, Douglas T. Golenbock Cell

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Presentation transcript:

Beyond Empiricism: Informing Vaccine Development through Innate Immunity Research Stuart M. Levitz, Douglas T. Golenbock Cell Volume 148, Issue 6, Pages 1284-1292 (March 2012) DOI: 10.1016/j.cell.2012.02.012 Copyright © 2012 Elsevier Inc. Terms and Conditions

Figure 1 PRRs Targeted by Vaccine Adjuvants TLR1, TLR2, TLR4, TLR5, and TLR6 are located on the cell surface. TLR2 forms a heterodimer with TLR1 or TLR6. TLR3, TLR7, and TLR9 translocate from the endoplasmic reticulum to endolysosomal compartments following cell stimulation. The CLRs are cell surface receptors, whereas the NLRs and RLRs reside in cytoplasm. The interaction of a PRR with its cognate ligand results in initiation of a signaling cascade leading to inflammatory responses. Cell 2012 148, 1284-1292DOI: (10.1016/j.cell.2012.02.012) Copyright © 2012 Elsevier Inc. Terms and Conditions