G. R. Dodge, A. J. Farran, R. Cocca, G. Meloni, B. Mohanraj, A

Slides:

Advertisements

Similar presentations

Full-thickness cartilage defects repaired by human induced pluripotent stem cells (IPSCS)-derived mesenchymal stem cells and plga scaffolds D. Shi, X.

Advertisements

Full-thickness cartilage defects repaired by human induced pluripotent stem cells (IPSCS)-derived mesenchymal stem cells and plga scaffolds D. Shi, X.

A. Bhave, M. Mont, M. Chugthai, R. Starr Osteoarthritis and Cartilage

R. Takeuchi, H. Ishikawa, T. Kuniya, A. Nakazawa

K.S. Santangelo Osteoarthritis and Cartilage

S. Gavard Osteoarthritis and Cartilage

Isotropic three-dimensional T2 mapping of knee cartilage with T2-prepared segmented gradient ECHO at 3T R. Colotti, P. Omoumi, R.B. van Heeswijk Osteoarthritis.

Injectable hydrogels for cartilage repair

Prospective economic evaluation of the costs for medications and nutraceuticals in knee osteoarthritis M. Chung, N. Zhao, J.B. Wong, C. Wang Osteoarthritis.

Characterization of cartilage repair in a focal mouse defect model

Does a yoga-strengthening program for women with knee osteoarthritis have an effect on gait patterns? An investigation with principal components analysis

Decreased proteoglycan degradation in IL-1β-treated cartilage co-cultured with TIMP-3- transduced cells J. Mason, A. Donahue, A. Yoskowitz, D. Richardson

M. Kim, J.A. Burdick, R.L. Mauck Osteoarthritis and Cartilage

Role of endothelin-1 in endochondral ossification and osteoarthritis

Automatic cartilage segmentation and measurement for diagnosis of OA using 3D box and Gaussian filters X. Cui, S. Li, M. Yu, H. Kim, K.-S. Kwack, B.-H.

Mineralization of meniscal enthesis in osteoarthritic knees

Effect of self assembled peptide-mesenchymal stem cell complex on delaying the progression of osteoarthritis S. Kim, S. Lee, Y. Jung, J. Kim, S. Kim

M. Finnilä, O-M. Aho, V. Tiitu, J. Thevenot, J. Rautiainen, M

G. Venne, S. Pang, Y. Tse, R. Ellis Osteoarthritis and Cartilage

High flexion is associated with knee osteoarthritis - of four high flexion postures, flat foot squatting minimizes knee adduction moments H.C. Chong,

Effect of mechanical stress on the hypertrophic differentiation related gene expression in cultured chondrocytes H. Inoue, Y. Arai, R. Terauchi, S. Nakagawa,

Evaluation of TRB-n0224, a Chemically Modified Curcumin for the Treatment of Osteoarthritis R. Nixon, J. Coury, S.S. Shah, N. Chahine, T. Goldstein,

Z. Zhang, W. Liao, Z. Zhang, X. Duan, C. Hou

The differences on extracellular matrix among each portion of meniscus

Replicability of recommended exercise interventions for knee osteoarthritis: a descriptive systematic review of current clinical guidelines and recommendations

Demineralized bone matrix and platelet-rich plasma do not improve healing of osteochondral defects of the talus: an experimental goat study C.J.A. van.

P. Yuan, X. Zhang, W. Yang, W. Kang, B. Yang, J. li, B. Chen, X. Li, B

Association of ultrasound-defined structural changes with regional and diffuse knee pain patterns – Oulu Knee Osteoarthritis study J. Podlipská, P. Kaukinen,

R. Nakamura, N. Komatsu, K. Fujita, H. Nishimura, Y. Katsuki

B. Vafaeian, S. Adeeb, M. El-Rich, J. Jaremko

Mice with global deletion of mitogen inducible gene 6 display rapid and severe cartilage and subchondral bone damage after ligament and meniscus injury

Different responses of healthy, relative healthy and OA chondrocytes with IL1β treatment under hypoxia and normoxia X. Huang, L. Zhong, J. Post, M. Karperien

A new lipid formulation of low dose (1200mg) ibuprofen is non-inferior to high dose (2400mg) standard ibuprofen capsules in managing episodic knee pain.

Y. Levy, A. Hasegawa, S. Patil, M. Lotz, D. D'Lima

MIR-455-3P and HDACs co-regulate chondrogenesis

M.N. Khan, M.Y. Ansari, T.M. Haqqi Osteoarthritis and Cartilage

G. Plumton, I. Adjei, A. Martin-Pena, G.D. Palmer, B. Sharma

Differential response of placebo treatments in osteoarthritis trials: a systematic review and network meta-analysis R.R. Bannuru, C.H. Schmid, M.C. Sullivan,

A cartilage-targeted insulin-like growth factor-1 is retained in cartilage and promotes extracellular matrix maintenance in rat medial meniscus tear model

Patellofemoral Bone Morphology is Related to Gender But Not Pain: 3D Quantitative Data Analysis From The OAI M.A. Bowes, B.T. Drew, A.C. Redmond, B.

Spontaneous home cage activity is sensitive to anti-NGF treatment or can be linked to joint stiffness in different models of surgery-induced osteoarthritis

Emerging role of endothelin receptor type B in regulating chondrogenic and hypertrophic changes of human mesenchymal stem cells M. Au, M. Zhu, W.-J.

Z. Huang, T. Stabler, F. Pei, V. Kraus Osteoarthritis and Cartilage

R. L. Trevino, C. A. Pacione, S. Chubinskaya, A. -M. Malfait, M. A

3D-histopathological grading of articular cartilage using contrast-enhanced high- resolution micro-CT H. Gahunia, S. Karhula, T. Ylitalo, E. Hæggström,

Evidence for bone mineral density and bone resorption in middle and elderly women with knee osteoarthritis in Shanghai: a cross sectional study Q. Xiaofeng

Walking with increased foot progression angle can reduce joint compression in individuals with knee OA K. Manal, T.S. Buchanan Osteoarthritis and Cartilage

Monocyte chemoattractant protein 1 induced chondrocytes degeneration and cartilage degradation in osteoarthritis X. yuankun, K. Yan, W. Bin, L. Jian-Hao

Osteoarthritis and Cartilage

The roles of connexin 43 in experimental arthritis

Multivariate pattern analysis of physical activity and cartilage health: data from the osteoarthritis initiative E. Halilaj, T.J. Hastie, G.E. Gold,

K.D. Novakofski, R.M. Williams, L.J. Bonassar, L.A. Fortier

K. -C. Wang, E. Kwan, K. Aris, T. T. Egelhoff, A. I. Caplan, J. F

Location-specific hip joint space width for progression of hip osteoarthritis: predictive validity and responsiveness of a new computerized measure C.

Imaging biomarker with T1 and T2 mappings in osteoarthritis – In vivo human articular cartilage study C. Yan, C. Wong, T. Li, N. Gong, Q. Chan, K. Chiu

How does lower leg alignment differ between soccer players, other athletes and non- athletic controls? W. colyn, R. Agricola, N. Arnout, J. Verhaar, J.

B. Mohanraj, M. Kim, F. Tu, D. Lee, R.L. Mauck, G.R. Dodge

Comparative evaluations of matrix alterations in the ovine menisci following joint injury or reconstructive surgery K. Barton, M. Wiebe, Y. Achari, C.B.

CD14 deficiency dampens osteoclastogenesis and alters bone remodeling in a murine model of osteoarthritis C. Zhou, V. Nguyen, R. Smalley, N. Sambamurthy,

H. Khan, D. Aitken, C. Ding, L. Blizzard, J. -P. Pelletier, J

Knee kinematic and kinetic modifications under body weight unloading during overground walking at a constant speed A.G. Fischer, E.M. Debbi, A. Wolf

Adhesive barrier/directional controlled release for cartilage repair by endogenous progenitor cell recruitment G.-I. Im, J.-M. Lee, E.-A. Kim Osteoarthritis.

Amyloid micronetworks for cartilage repair

In situ evaluation of chondrofix® osteochondral allograft 25 months following implantation: A case report K.L. Reynolds, S.K. Bishai Osteoarthritis.

Quadriceps/Hamstrings co-activation during gait in individuals with anterior cruciate ligament reconstruction T. Blackburn, B. Pietrosimone, J. Goodwin,

K. -C. Wang, E. Kwan, K. Aris, T. T. Egelhoff, A. I. Caplan, J. F

Hypertrophy and structural alterations in tibiofemoral articular cartilage 6-24 months after anterior cruciate ligament reconstruction E. Thorhauer,

A. Carlson, B. Bothner, R. June Osteoarthritis and Cartilage

General Information Osteoarthritis and Cartilage

Long-term effects of vitamin d supplementation and maintaining vitamin d sufficiency on knee osteoarthritis over 5 years B. Antony, S. Zheng, J. Burgess,

Presentation transcript:

Enhanced integration with treatment of Sprifermin (rhfgf18) in a cartilage injury-repair model G.R. Dodge, A.J. Farran, R. Cocca, G. Meloni, B. Mohanraj, A. Gigout, R.L. Mauck Osteoarthritis and Cartilage Volume 22, Pages S150-S151 (April 2014) DOI: 10.1016/j.joca.2014.02.280 Copyright © 2014 Terms and Conditions

Figure 1 Preparation of cartilage-defect repair model: (A) 8mm cartilage plug, (B) central 4mm defect creation, (C) insertion of cartilage into defect, and (D) long term culture of repair construct. Osteoarthritis and Cartilage 2014 22, S150-S151DOI: (10.1016/j.joca.2014.02.280) Copyright © 2014 Terms and Conditions

Figure 2 (A-C) Transverse cross sections of 3D μCT reconstruction with different treatments. (D) Integration strength of the repaired defect showing increasing strength from the control to the 1+30 treatment to the 1+6 treatment. (E) Experimental setup of the push-out testing rig. Error bars are SEM. Osteoarthritis and Cartilage 2014 22, S150-S151DOI: (10.1016/j.joca.2014.02.280) Copyright © 2014 Terms and Conditions

Figure 3 μCT scans of cartilage-to-cartilage repair constructs. Left: single μCT scan slice representative of the sample. Center: three dimensional reconstruction. Right: cross-section of the reconstruction. The μCT scans demonstrate increasing integration from control to 1+30 to 1+6 treatments. Osteoarthritis and Cartilage 2014 22, S150-S151DOI: (10.1016/j.joca.2014.02.280) Copyright © 2014 Terms and Conditions