Insect-sting challenge in 324 subjects with a previous anaphylactic reaction: Current criteria for insect-venom hypersensitivity do not predict the occurrence.

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Presentation transcript:

Insect-sting challenge in 324 subjects with a previous anaphylactic reaction: Current criteria for insect-venom hypersensitivity do not predict the occurrence and the severity of anaphylaxis van der Linden, MD, Hack, MD, Struyvenberg, MD, van der Zwan, MDc† Journal of Allergy and Clinical Immunology Volume 94, Issue 2, Pages 151-159 (August 1994) DOI: 10.1053/ai.1994.v94.a54889

FIG. 1 Relationship between skin test results and the clinical reaction after sting challenge in 324 subjects. Values for skin tests (log scale) to insect venom are compared with the clinical reaction after insect-sting challenge in 324 individual subjects with a previous anaphylactic reaction to either a honeybee or a yellow jacket sting. (See Methods for skin tests and grades of reaction.) Each dot represents one subject. Question marks indicate subjects in whom the skin tests were not obtainable. Journal of Allergy and Clinical Immunology 1994 94, 151-159DOI: (10.1053/ai.1994.v94.a54889)

FIG. 2 Relationship between insect-specific IgE and the clinical reaction after sting challenge in 324 subjects. Individual results for levels of insect-specific IgE (RAST class) are compared with the clinical reaction after a sting challenge with either a honeybee or a yellow jacket sting. (See legend to Fig. 1 for explanation.) Journal of Allergy and Clinical Immunology 1994 94, 151-159DOI: (10.1053/ai.1994.v94.a54889)

FIG. 3 Relationship between insect-specific IgG4 and the clinical reaction after sting challenge in 324 subjects. Individual results for levels of insect-specific IgG4 (U/ml, log scale) are compared with the clinical reaction after a sting challenge with either a honeybee or a yellow jacket sting. (See legend to Fig. 1 for explanation.) Journal of Allergy and Clinical Immunology 1994 94, 151-159DOI: (10.1053/ai.1994.v94.a54889)