Mean (+SEM) urinary (5αTHF+5βTHF)/THE ratio as measure of 11βHSD1 inhibition (PP population). Randomised treatment (RO5093151/placebo) started on day 1 and lasted until day 7. PP, per-protocol; THE, tetrahydrocortisone; THF, tetrahydrocortisol. Mean (+SEM) urinary (5αTHF+5βTHF)/THE ratio as measure of 11βHSD1 inhibition (PP population). Randomised treatment (RO5093151/placebo) started on day 1 and lasted until day 7. PP, per-protocol; THE, tetrahydrocortisone; THF, tetrahydrocortisol. Dietmar Schwab et al. BMJ Open Ophth 2017;1:e000063 © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.