Engineering Skin with Skinny Genes

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Engineering Skin with Skinny Genes Anika Böttcher, Heiko Lickert, Matthias Tschöp Cell Stem Cell Volume 21, Issue 2, Pages 153-155 (August 2017) DOI: 10.1016/j.stem.2017.07.013 Copyright © 2017 Terms and Conditions

Figure 1 Engineered Skin Cells for Gene Therapy to Fight Metabolic Diseases The schematic shows the potential therapeutic effects of cutaneous gene therapy. Epidermal stem cells/progenitor cells are genetically modified in vitro using CRISPR/Cas9 technology to inducibly express the incretin hormone GLP-1. An organotypic culture model enables stratification of epidermal progenitor cells and formation of skin-like organoids, which can then be transplanted to a patient for treatment. Cutaneous delivered GLP-1 may prevent diet-induced weight gain and insulin resistance, directly affecting pancreas and brain with indirect influence on adipose tissue and liver. Cell Stem Cell 2017 21, 153-155DOI: (10.1016/j.stem.2017.07.013) Copyright © 2017 Terms and Conditions