Volume 155, Issue 2, Pages (October 2013)

Slides:

Advertisements

Similar presentations

The Bacterial DnaC Helicase Loader Is a DnaB Ring Breaker Ernesto Arias-Palomo, Valerie L. O’Shea, Iris V. Hood, James M. Berger Cell Volume 153, Issue.

Advertisements

Exogenous Stimuli Maintain Intraepithelial Lymphocytes via Aryl Hydrocarbon Receptor Activation Ying Li, Silvia Innocentin, David R. Withers, Natalie A.

SOD1 Integrates Signals from Oxygen and Glucose to Repress Respiration Amit R. Reddi, Valeria C. Culotta Cell Volume 152, Issue 1, Pages (January.

Individualized Medicine from Prewomb to Tomb Eric J. Topol Cell Volume 157, Issue 1, Pages (March 2014) DOI: /j.cell Copyright.

The RAG Recombinase Dictates Functional Heterogeneity and Cellular Fitness in Natural Killer Cells Jenny M. Karo, David G. Schatz, Joseph C. Sun Cell Volume.

The Cell-Non-Autonomous Nature of Electron Transport Chain-Mediated Longevity Jenni Durieux, Suzanne Wolff, Andrew Dillin Cell Volume 144, Issue 1, Pages.

Bleach Activates a Redox-Regulated Chaperone by Oxidative Protein Unfolding J. Winter, M. Ilbert, P.C.F. Graf, D. Özcelik, U. Jakob Cell Volume 135, Issue.

Mapping the Human miRNA Interactome by CLASH Reveals Frequent Noncanonical Binding Aleksandra Helwak, Grzegorz Kudla, Tatiana Dudnakova, David Tollervey.

What We Talk About When We Talk About Fat Evan D. Rosen, Bruce M. Spiegelman Cell Volume 156, Issue 1, Pages (January 2014) DOI: /j.cell

3.3 Å Cryo-EM Structure of a Nonenveloped Virus Reveals a Priming Mechanism for Cell Entry Xing Zhang, Lei Jin, Qin Fang, Wong H. Hui, Z. Hong Zhou Cell.

Treatment of Obesity with Celastrol

Tissue-Resident Macrophage Enhancer Landscapes Are Shaped by the Local Microenvironment Yonit Lavin, Deborah Winter, Ronnie Blecher-Gonen, Eyal David,

Growing Dendrites and Axons Differ in Their Reliance on the Secretory Pathway Bing Ye, Ye Zhang, Wei Song, Susan H. Younger, Lily Yeh Jan, Yuh Nung Jan.

Origins of Metastatic Traits Sakari Vanharanta, Joan Massagué Cancer Cell Volume 24, Issue 4, Pages (October 2013) DOI: /j.ccr

Maintaining Cell Identity through Global Control of Genomic Organization Gioacchino Natoli Immunity Volume 33, Issue 1, Pages (July 2010) DOI: /j.immuni

A Long ncRNA Links Copy Number Variation to a Polycomb/Trithorax Epigenetic Switch in FSHD Muscular Dystrophy Daphne S. Cabianca, Valentina Casa, Beatrice.

Common Sense about Taste: From Mammals to Insects David A. Yarmolinsky, Charles S. Zuker, Nicholas J.P. Ryba Cell Volume 139, Issue 2, Pages (October.

Genome-wide Single-Cell Analysis of Recombination Activity and De Novo Mutation Rates in Human Sperm Jianbin Wang, H. Christina Fan, Barry Behr, Stephen.

UvrD Helicase Unwinds DNA One Base Pair at a Time by a Two-Part Power Stroke Jae Young Lee, Wei Yang Cell Volume 127, Issue 7, Pages (December.

Distribution of Human Embryonic Stem Cell Lines: Who, When, and Where Jennifer B. McCormick, Jason Owen-Smith, Christopher Thomas Scott Cell Stem Cell.

Nucleation and Transport Organize Microtubules in Metaphase Spindles Jan Brugués, Valeria Nuzzo, Eric Mazur, Daniel J. Needleman Cell Volume 149, Issue.

Eph-Ephrin Bidirectional Signaling in Physiology and Disease Elena B. Pasquale Cell Volume 133, Issue 1, Pages (April 2008) DOI: /j.cell

Cancer Metabolism Cell Volume 148, Issue 3, (February 2012) DOI: /j.cell Copyright © 2012 Terms and Conditions Terms and Conditions.

ΓCaMKII Shuttles Ca2+/CaM to the Nucleus to Trigger CREB Phosphorylation and Gene Expression Huan Ma, Rachel D. Groth, Samuel M. Cohen, John F. Emery,

Structurally Distinct Ca2+ Signaling Domains of Sperm Flagella Orchestrate Tyrosine Phosphorylation and Motility Jean-Ju Chung, Sang-Hee Shim, Robert A.

The Monarch Butterfly Genome Yields Insights into Long-Distance Migration Shuai Zhan, Christine Merlin, Jeffrey L. Boore, Steven M. Reppert Cell Volume.

Dynein Anchors Its mRNA Cargo after Apical Transport in the Drosophila Blastoderm Embryo Renald Delanoue, Ilan Davis Cell Volume 122, Issue 1, Pages

Nuclear Receptors, RXR, and the Big Bang Ronald M. Evans, David J. Mangelsdorf Cell Volume 157, Issue 1, Pages (March 2014) DOI: /j.cell

Transmembrane Receptor DCC Associates with Protein Synthesis Machinery and Regulates Translation Joseph Tcherkezian, Perry A. Brittis, Franziska Thomas,

Writing Memories with Light-Addressable Reinforcement Circuitry Adam Claridge-Chang, Robert D. Roorda, Eleftheria Vrontou, Lucas Sjulson, Haiyan Li, Jay.

The Landscape of Microsatellite Instability in Colorectal and Endometrial Cancer Genomes Tae-Min Kim, Peter W. Laird, Peter J. Park Cell Volume 155, Issue.

IPSC Crowdsourcing: A Model for Obtaining Large Panels of Stem Cell Lines for Screening Mahendra Rao Cell Stem Cell Volume 13, Issue 4, Pages (October.

Human Brown Adipose Tissue Sven Enerbäck Cell Metabolism Volume 11, Issue 4, Pages (April 2010) DOI: /j.cmet Copyright © 2010.

The Good Fat Cell Volume 147, Issue 7, (December 2011) DOI: /j.cell Copyright © 2011 Terms and Conditions Terms and Conditions.

Communicable Ulcerative Colitis Induced by T-bet Deficiency in the Innate Immune System Wendy S. Garrett, Graham M. Lord, Shivesh Punit, Geanncarlo Lugo-Villarino,

SRC-3 Coactivator Functional Lifetime Is Regulated by a Phospho-Dependent Ubiquitin Time Clock Ray-Chang Wu, Qin Feng, David M. Lonard, Bert W. O'Malley.

Revisiting Global Gene Expression Analysis Jakob Lovén, David A. Orlando, Alla A. Sigova, Charles Y. Lin, Peter B. Rahl, Christopher B. Burge, David L.

Germline Energetics, Aging, and Female Infertility Jonathan L. Tilly, David A. Sinclair Cell Metabolism Volume 17, Issue 6, Pages (June 2013) DOI:

Shaping Genetic Alterations in Human Cancer: The p53 Mutation Paradigm Thierry Soussi, Klas G. Wiman Cancer Cell Volume 12, Issue 4, Pages (October.

Mutually Exclusive Binding of Telomerase RNA and DNA by Ku Alters Telomerase Recruitment Model Jennifer S. Pfingsten, Karen J. Goodrich, Cornelius Taabazuing,

Sensory Detection of Food Rapidly Modulates Arcuate Feeding Circuits Yiming Chen, Yen-Chu Lin, Tzu-Wei Kuo, Zachary A. Knight Cell Volume 160, Issue 5,

SSB Functions as a Sliding Platform that Migrates on DNA via Reptation Ruobo Zhou, Alexander G. Kozlov, Rahul Roy, Jichuan Zhang, Sergey Korolev, Timothy.

Expanding the Biologist’s Toolkit with CRISPR-Cas9

Unweaving the Autism Spectrum

Heavy Metal Enlightens Tumor Immunity

Mapping Human Epigenomes

The Proteasome: Not Just Degrading Anymore

Volume 159, Issue 5, Pages (November 2014)

The Whole (Cell) Is Less Than the Sum of Its Parts

In This Issue Cell Volume 158, Issue 5, (August 2014)

Calorie Restriction à Lamarck

FIX It in One Go: Enhanced Factor IX Gene Therapy for Hemophilia B

Cancer Genomes Evolve by Pulverizing Single Chromosomes

A Biomarker Harvest from One Thousand Cancer Cell Lines

Volume 152, Issue 1, (January 2013)

Volume 154, Issue 6, Pages (September 2013)

Volume 130, Issue 6, (September 2007)

Easy Stress Relief by EZH2

Volume 143, Issue 6, (December 2010)

Making the Most from Changes in Life

The Cell Biology of Genomes: Bringing the Double Helix to Life

Learning from the Uncontrollable

Deciphering Pancreatic Islet β Cell and α Cell Maturation Pathways and Characteristic Features at the Single-Cell Level Wei-Lin Qiu, Yu-Wei Zhang, Ye.

Volume 163, Issue 4, (November 2015)

Volume 163, Issue 2, (October 2015)

Volume 134, Issue 6, (September 2008)

David Hubel and Torsten Wiesel

In This Issue Cell Volume 145, Issue 3, (April 2011)

Volume 148, Issue 1, (January 2012)

Targeting Protein Stability with a Small Molecule

Presentation transcript:

Volume 155, Issue 2, Pages 479-480 (October 2013) Double Nicking by RNA-Guided CRISPR Cas9 for Enhanced Genome Editing Specificity F. Ann Ran, Patrick D. Hsu, Chie-Yu Lin, Jonathan S. Gootenberg, Silvana Konermann, Alexandro E. Trevino, David A. Scott, Azusa Inoue, Shogo Matoba, Yi Zhang, Feng Zhang Cell Volume 155, Issue 2, Pages 479-480 (October 2013) DOI: 10.1016/j.cell.2013.09.040 Copyright © 2013 Elsevier Inc. Terms and Conditions

Figure 2 Double Nicking Facilitates Efficient Genome Editing in Human Cells Cell 2013 155, 479-480DOI: (10.1016/j.cell.2013.09.040) Copyright © 2013 Elsevier Inc. Terms and Conditions

Figure 4 Double Nicking Allows Insertion into the Genome via HDR in Human Cells Cell 2013 155, 479-480DOI: (10.1016/j.cell.2013.09.040) Copyright © 2013 Elsevier Inc. Terms and Conditions