Volume 1, Issue 6, Pages (November 2015)

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Volume 1, Issue 6, Pages 368-370 (November 2015) Recurrent lobular capillary hemangiomas in a patient with neurofibromatosis type 1 (NF1) and von Hippel-Lindau syndrome (VHL) Karyn Haitz, BA, Anar Mikailov, MD, Ruth Foreman, MD, PhD, Mary Jane Zimarowski, MD, Su-Jean Seo, MD, PhD JAAD Case Reports Volume 1, Issue 6, Pages 368-370 (November 2015) DOI: 10.1016/j.jdcr.2015.08.012 Copyright © 2015 American Academy of Dermatology, Inc. Terms and Conditions

Fig 1 Two vascular papules on the right jawline and front of the right shoulder. Asymptomatic ill-defined soft nodule on the right upper lip. JAAD Case Reports 2015 1, 368-370DOI: (10.1016/j.jdcr.2015.08.012) Copyright © 2015 American Academy of Dermatology, Inc. Terms and Conditions

Fig 2 Multiple café au lait macules, axillary freckling, and neurofibromas on the torso and abdomen. JAAD Case Reports 2015 1, 368-370DOI: (10.1016/j.jdcr.2015.08.012) Copyright © 2015 American Academy of Dermatology, Inc. Terms and Conditions

Fig 3 Proliferating capillaries grouped into lobules by dense fibrous bands, clutched by an epithelial collarette. (Hematoxylin-eosin stain; original magnification: ×20.) JAAD Case Reports 2015 1, 368-370DOI: (10.1016/j.jdcr.2015.08.012) Copyright © 2015 American Academy of Dermatology, Inc. Terms and Conditions

Fig 4 Potential pathway for recurrent lobular capillary hemangiomas (LCH) in this patient. There are several well-known causes for lobular capillary hemangiomas.1 In the setting of von Hippel-Lindau syndrome (VHL), there is increased vascular endothelial growth factor (VEGF),5 which we hypothesize predisposes our patient to more frequent development of lobular capillary hemangiomas in the setting of minor trauma.9 AV, Arteriovenous; HIF, hypoxia inducible factor. JAAD Case Reports 2015 1, 368-370DOI: (10.1016/j.jdcr.2015.08.012) Copyright © 2015 American Academy of Dermatology, Inc. Terms and Conditions